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Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers
Abstract Applications of metalloporphyrins and related molecules have been extensively pursued in the context of photodynamic therapy of cancer (PDT) and other biomedical applications. This review… Expand
Design of Pluronic-Based Formulation for Enhanced Redaporfin-Photodynamic Therapy against Pigmented Melanoma.
- Barbara Pucelik, L. Arnaut, G. Stochel, J. Dąbrowski
- Materials Science, Medicine
- ACS applied materials & interfaces
- 18 August 2016
The therapeutic outcome of photodynamic therapy (PDT) with redaporfin (a fluorinated sulfonamide bacteriochlorin, F2BMet or LUZ11) was improved using Pluronic-based (P123, F127) formulations. Neither… Expand
Reactive Oxygen Species in Photodynamic Therapy: Mechanisms of Their Generation and Potentiation
- J. Dąbrowski
Abstract Reactive oxygen species (ROS) play key roles in cell signaling systems and homeostasis, and they are also fundamental to photodynamic therapy (PDT). PDT efficacy can be affected by the… Expand
Three-dimensional structure of the oligosaccharide chain of GM1 ganglioside revealed by a distance-mapping procedure: a rotating and laboratory frame nuclear overhauser enhancement investigation of…
Photodynamic therapy (PDT) of cancer: from local to systemic treatment.
Photodynamic therapy (PDT) requires a medical device, a photosensitizing drug and adequate use of both to trigger biological mechanisms that can rapidly destroy the primary tumour and provide… Expand
Mechanisms of singlet-oxygen and superoxide-ion generation by porphyrins and bacteriochlorins and their implications in photodynamic therapy.
New halogenated and sulfonated bacteriochlorins and their analogous porphyrins are employed as photosensitizers of singlet oxygen and the superoxide ion. The mechanisms of energy and electron… Expand
Solution conformations of GM3 gangliosides containing different sialic acid residues as revealed by NOE-based distance mapping, molecular mechanics, and molecular dynamics calculations.
- H. Siebert, G. Reuter, R. Schauer, C. W. von der Lieth, J. Dąbrowski
- Chemistry, Medicine
- 4 August 1992
The conformation of the GM3 ganglioside, Neu5Ac alpha 2-3Gal beta 1-4Glc beta 1-1 Cer, and its analogs containing the Neu5Gc or Neu4Ac5Gc residues (Gc = glycolyl, CH2OHCO) was investigated in… Expand
Photodynamic therapy efficacy enhanced by dynamics: the role of charge transfer and photostability in the selection of photosensitizers.
Progress in the photodynamic therapy (PDT) of cancer should benefit from a rationale to predict the most efficient of a series of photosensitizers that strongly absorb light in the phototherapeutic… Expand
Biodistribution and Photodynamic Efficacy of a Water‐Soluble, Stable, Halogenated Bacteriochlorin against Melanoma
The in vitro phototoxicity of a photostable, synthetic, water‐soluble, halogenated bacteriochlorin, 5,10,15,20‐tetrakis(2‐chloro‐5‐sulfophenyl)bacteriochlorin (TCPBSO3H), toward mouse melanoma (S91)… Expand
Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: evidence from intracellular fluorescence and increased photodynamic efficacy in…
- J. Dąbrowski, L. Arnaut, +4 authors L. Cortes
- Chemistry, Medicine
- Free radical biology & medicine
- 1 April 2012
Sulfonamides of halogenated bacteriochlorins bearing Cl or F substituents in the ortho positions of the phenyl rings have adequate properties for photodynamic therapy, including strong absorption in… Expand