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Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome.
- D. Silverman, G. Small, M. Phelps
- Medicine, PsychologyJAMA
- 7 November 2001
In patients presenting with cognitive symptoms of dementia, regional brain metabolism was a sensitive indicator of AD and of neurodegenerative disease in general and a negative PET scan indicated that pathologic progression of cognitive impairment during the mean 3-year follow-up was unlikely to occur.
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin.
- D. Shackelford, Evan R. Abt, R. Shaw
- Biology, ChemistryCancer Cell
- 11 February 2013
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
- G. Thomas, C. Tran, C. Sawyers
- Biology, MedicineNature Network Boston
- 2006
It is shown that loss of the Von Hippel-Lindau tumor suppressor gene (VHL) sensitizes kidney cancer cells to the mTOR inhibitor CCI-779 in vitro and in mouse models, providing preclinical rationale for prospective, biomarker-driven clinical studies of mTOR inhibitors in kidney cancer.
18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy.
- Wei Chen, D. Silverman, T. Cloughesy
- Medicine, BiologyJournal of nuclear medicine : official…
- 1 June 2006
18)F-FDOPA PET may prove especially useful for imaging of recurrent low-grade tumors and for distinguishing tumor recurrence from radiation necrosis, as determined by simple visual inspection, especially for the assessment of low- grade tumors.
A meta-analysis of the literature for whole-body FDG PET detection of recurrent colorectal cancer.
- R. H. Huebner, K. Park, S. Gambhir
- MedicineJournal of Nuclear Medicine
- 1 July 2000
The overall values determined through the meta-analysis indicate the potential benefits of using FDG PET as a diagnostic or management tool and should prove to be useful to assess the cost-effectiveness of usingFDG PET in the management of patients with recurrent CRC.
Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG.
- Wei Chen, T. Cloughesy, D. Silverman
- Medicine, BiologyJournal of nuclear medicine : official…
- 1 June 2005
Thirty-minute PET of brain gliomas 5 min after injection was more sensitive than (18)F-FDG to image recurrent high-grade tumors, correlated better with Ki-67 values, and was a more powerful predictor of tumor progression and survival.
A tabulated summary of the FDG PET literature.
- S. Gambhir, J. Czernin, J. Schwimmer, D. Silverman, R. Coleman, M. Phelps
- MedicineJournal of nuclear medicine : official…
- 1 May 2001
Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction.
- M. D. Di Carli, M. Davidson, H. Laks
- MedicineAmerican Journal of Cardiology
- 15 March 1994
Influence of Age and Hemodynamics on Myocardial Blood Flow and Flow Reserve
- J. Czernin, P. Muller, H. Schelbert
- MedicineCirculation
- 1 July 1993
The findings suggest that the reduced flow reserve with age is primarily due to increased cardiac work and blood flow at rest rather than to an abnormal vasodilator capacity.
Impact of animal handling on the results of 18F-FDG PET studies in mice.
- B. Fueger, J. Czernin, W. Weber
- Biology, MedicineJournal of Nuclear Medicine
- 1 June 2006
Animal handling has a dramatic effect on (18)F-FDG biodistribution and significantly influences the results of microPET studies in tumor-bearing mice and should be fasted and warmed before and during the uptake period to improve tumor visualization mice.
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