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A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: a multicenter trial.
BACKGROUND Adapalene is a new synthetic retinoid analogue developed for the topical treatment of acne vulgaris. OBJECTIVE The study was designed to compare the efficacy and safety and adapalene gelExpand
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Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study.
This multicenter, randomized, investigator-blinded study investigated the efficacy and tolerability of adapalene gel 0.1% plus clindamycin phosphate lotion 1%, compared with clindamycin plus vehicleExpand
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Clinical efficacy and safety comparison of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and U.S. multicenter trials.
BACKGROUND Adapalene is a new chemical entity that exhibits tretinoin-like activities in the terminal differentiation process. OBJECTIVE We evaluated a dose range effect of two concentrations ofExpand
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Comparison of eicosanoid generation by highly purified human Langerhans cells and keratinocytes.
The present study was conducted to investigate the eicosanoid metabolism of highly enriched human Langerhans cells and keratinocytes. Arachidonic acid (100 microM) was added to the cells which wereExpand
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A randomized trial of amorolfine 5% solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic toenail onychomycoses affecting the matrix
In view of recent advances in the development of antifungal agents, this study examined the possible synergy of two new antifungal agents, terbinafine and amorolfine. The study compared two differentExpand
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Topical metronidazole maintains remissions of rosacea.
BACKGROUND Rosacea is a chronic skin disease that requires long-term therapy. Oral antibiotics and topical metronidazole successfully treat rosacea. Because long-term use of systemic antibioticsExpand
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Topical retinoids. Their uses in dermatology.
The retinoids provide an important new way of treating dermatologic disorders. They have also proved to have a role in the prevention of new lesion formation. New retinoids, of which adapalene isExpand
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Efficacy and safety of CD 271 alcoholic gels in the topical treatment of acne vulgaris
CD 271, a naphthoic acid, is a powerful modulator of epidermal differentiation. This double‐blind, randomized study compared the efficacy and safety of two concentrations (0.03% w/w and 0.1% w/w) ofExpand
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Physiology of the vellus hair follicle: hair growth and sebum excretion
Summary The growth of vellus hair and the secretion of sebum from vellus hair follicles were measured on the forehead, cheek, chest, shoulder and back of healthy men and women aged 15–30 years. HairExpand
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Lymecycline in the treatment of acne: an efficacious, safe and cost-effective alternative to minocycline.
A comparison of efficacy, safety and cost-effectiveness of lymecycline and minocycline in the treatment of acne vulgaris has been addressed. This was a multicenter, randomized, investigator-masked,Expand
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