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Sulfo-N-succinimidyl Oleate (SSO) Inhibits Fatty Acid Uptake and Signaling for Intracellular Calcium via Binding CD36 Lysine 164
SSO accesses Lys-164 in the FA-binding site on CD36, and initial modeling of this site is presented, suggesting competition between FA and oxLDL for access to the CD36 binding pocket.
MALDI imaging of neutral cuticular lipids in insects and plants
The spatial distribution of neutral lipids and hydrocarbons has been imaged using MALDI-TOF mass spectrometry on intact plant and insect surfaces, namely wings and legs of the gray flesh fly, wings of common fruit fly, leaves of thale cress, Arabidopsis thaliana, and leaves of date palm tree.
Analysis of wax ester molecular species by high performance liquid chromatography/atmospheric pressure chemical ionisation mass spectrometry.
High chromatographic resolution of wax esters (WEs) was achieved by non-aqueous reversed-phase liquid chromatography on a Nova-Pak C18 column by optimising the acetonitrile/ethyl acetate mobile phase
Dinucleoside polyphosphates act as 5′-RNA caps in bacteria
It is demonstrated, that the E. coli enzymes RNA 5′-pyrophosphohydrolase (RppH) and bis(5′-nucleosyl)-tetraphosphatase (ApaH) are able to remove the Np n N-caps from RNA.
Regioisomeric analysis of triacylglycerols using silver-ion liquid chromatography-atmospheric pressure chemical ionization mass spectrometry: comparison of five different mass analyzers.
Silver-ion high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry (APCI-MS) is used for the regioisomeric analysis of triacylglycerols (TGs) and presented data on [M+H-R(i)COOH](+) ratios measured on five different mass analyzers can be used in natural and biological samples.
Melectin: A Novel Antimicrobial Peptide from the Venom of the Cleptoparasitic Bee Melecta albifrons
The results of biological testing suggest that a Pro kink in the α‐helical structure of melectin plays an important role in selectivity for bacterial cells.
Explosive Backpacks in Old Termite Workers
It is shown that workers of the termite Neocapritermes taracua develop an exceptional two-component suicidal apparatus consisting of copper-containing protein crystals, stored in external pouches, and internal salivary glands that bursts during aggressive encounters.
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
Eight C-6-geranylflavonoids were isolated from an ethanol extract of Paulownia tomentosa fruits and obtained as new compounds, and 3'- O-methyldiplacol was isolated for the first time from a natural source.
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
One of the COX/LOX dual inhibitors, diplacone (14) (a major geranylated flavanone of P. tomentosa), was studied in vitro to obtain a proteomic overview of its effect on inflammation in LPS-treated THP-1 macrophages, supporting its previously observed anti-inflammatory activity and revealing the mechanism of its anti- inflammatory effect.
Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra.
The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.