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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
- R. Houghten, C. Pinilla, S. Blondelle, J. Appel, C. Dooley, J. Cuervo
- Biology, Medicine
- 7 November 1991
EXISTING methods for the synthesis and screening of large numbers of peptides are limited by their inability to generate and screen the requisite number (millions) of individual peptides1–4 and/or… Expand
The Magainins: sequence factors relevant to increased antimicrobial activity and decreased hemolytic activity.
The Magainins, two antimicrobial peptides found in the skin of the frog Xenopus laevis, and 50 Magainin analogs were synthesized by the method of simultaneous multiple peptide synthesis (SMPS). This… Expand
The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.
- R. Houghten, J. Appel, S. Blondelle, J. Cuervo, C. Dooley, C. Pinilla
- Chemistry, Medicine
- 1 September 1992
The systematic preparation of synthetic peptide combinatorial libraries (SPCLs), each composed of tens of millions of peptides that can be screened in existing diagnostically or pharmacologically… Expand
Identification of ligand binding sites on integrin alpha4beta1 through chemical cross-linking.
- L. Chen, R. Lobb, J. Cuervo, K. Lin, S. Adams, R. Pepinsky
- Chemistry, Medicine
- 27 May 1998
We have used chemical cross-linking to identify sequences in integrin alpha4beta1 that are involved in its interactions with ligands. A recently described leucine-aspartic acid-valine (LDV)-based… Expand
3D QSAR (COMFA) of a series of potent and highly selective VLA-4 antagonists
- J. Singh, H. Vlijmen, +10 authors S. Adams
- Chemistry, Computer Science
- J. Comput. Aided Mol. Des.
- 1 March 2002
The integrin VLA-4 (α4β1) is involved in the migration of white blood cells to sites of inflammation, and is implicated in the pathology of a variety of diseases including asthma and multiple sclerosis. Expand
Polyalkylamine chemical combinatorial libraries
Optimal peptide length determination using synthetic peptide combinatorial libraries
The use of a peptide library composed of 34 012 224 hexamers for basic research and drug discovery
Synthesis of oligomeric multiple equimolar mixtures, especially mixtures oligopeptide.
It IS SHOWN A process for the synthesis of a mix grouping COMPLEX COMPOUNDS REPEATER UNIT COUPLED TO SUPPORT monomeric solid as amino acid derivatives in which the mixture contains a GROUPING OF… Expand
Molecules de liaison et leurs procedes d'utilisation