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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
EXISTING methods for the synthesis and screening of large numbers of peptides are limited by their inability to generate and screen the requisite number (millions) of individual peptides1–4 and/orExpand
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The Magainins: sequence factors relevant to increased antimicrobial activity and decreased hemolytic activity.
The Magainins, two antimicrobial peptides found in the skin of the frog Xenopus laevis, and 50 Magainin analogs were synthesized by the method of simultaneous multiple peptide synthesis (SMPS). ThisExpand
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The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.
The systematic preparation of synthetic peptide combinatorial libraries (SPCLs), each composed of tens of millions of peptides that can be screened in existing diagnostically or pharmacologicallyExpand
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Identification of ligand binding sites on integrin alpha4beta1 through chemical cross-linking.
We have used chemical cross-linking to identify sequences in integrin alpha4beta1 that are involved in its interactions with ligands. A recently described leucine-aspartic acid-valine (LDV)-basedExpand
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3D QSAR (COMFA) of a series of potent and highly selective VLA-4 antagonists
The integrin VLA-4 (α4β1) is involved in the migration of white blood cells to sites of inflammation, and is implicated in the pathology of a variety of diseases including asthma and multiple sclerosis. Expand
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Synthesis of oligomeric multiple equimolar mixtures, especially mixtures oligopeptide.
It IS SHOWN A process for the synthesis of a mix grouping COMPLEX COMPOUNDS REPEATER UNIT COUPLED TO SUPPORT monomeric solid as amino acid derivatives in which the mixture contains a GROUPING OFExpand