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Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
CONTEXT In addition to trauma exposure, other factors contribute to risk for development of posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors are contributory,… Expand
Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.
- Rebekah G Bradley, E. Binder, +13 authors K. Ressler
- Psychology, Medicine
- Archives of general psychiatry
- 1 February 2008
CONTEXT Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and trauma alter the endogenous stress response, principally… Expand
Trauma exposure and stress-related disorders in inner city primary care patients.
OBJECTIVE This study was undertaken to increase understanding of environmental risk factors for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) within an urban, impoverished,… Expand
Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects
Abstract The SLC6A4 locus encodes the serotonin transporter, which in turn mediates the synaptic inactivation of the neurotransmitter serotonin. Two PCR-formatted polymorphisms at this locus have… Expand
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.
- C. Zabetian, G. Anderson, +8 authors J. Cubells
- Biology, Medicine
- American journal of human genetics
- 1 February 2001
Dopamine-beta-hydroxylase (D beta H) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Plasma-D beta H activity varies widely… Expand
Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress
- J. Cubells, S. Rayport, G. Rajendran, D. Sulzer
- Biology, Medicine
- The Journal of neuroscience : the official…
- 1 April 1994
Methamphetamine (MA) produces selective degeneration of dopamine (DA) neuron terminals without cell body loss. While excitatory amino acids (EAAs) contribute to MA toxicity, terminal loss is not… Expand
A haplotype at the DBH locus, associated with low plasma dopamine β-hydroxylase activity, also associates with cocaine-induced paranoia
Low levels of dopamine β-hydroxylase (DβH) protein in the plasma or cerebrospinal fluid (CSF) are associated with greater vulnerability to positive psychotic symptoms in several psychiatric… Expand
Population studies of polymorphisms of the serotonin transporter protein gene.
- J. Gelernter, J. Cubells, J. Kidd, A. Pakstis, K. Kidd
- Biology, Medicine
- American journal of medical genetics
- 5 February 1999
The range of allele frequency variation in humans for any locus that may have functionally important genetic variation needs to be documented. Therefore, we tested two polymorphisms at the serotonin… Expand
Differential immune system DNA methylation and cytokine regulation in post‐traumatic stress disorder
- A. Smith, K. Conneely, +7 authors K. Ressler
- American journal of medical genetics. Part B…
- 1 September 2011
DNA methylation may mediate persistent changes in gene function following chronic stress. To examine this hypothesis, we evaluated African American subjects matched by age and sex, and stratified… Expand
Dopamine β-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation
Levels of the enzyme dopamine β-hydroxylase (DβH) in the plasma and cerebrospinal fluid (CSF) are closely related biochemical phenotypes. Both are under strong genetic control. Linkage and… Expand