• Publications
  • Influence
Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements.
TLDR
It is hypothesized that automatic spike-sorting algorithms have the potential to significantly lower error rates, and implementation of a semi-automatic classification system confirms this suggestion, reducing errors close to the estimated optimum, in the range 0-8%. Expand
Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving Rat
TLDR
It is suggested that network-driven excitability changes provide temporal windows of opportunity for single pyramidal cells to suppress, enable, or facilitate selective synaptic inputs. Expand
Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat
TLDR
This work examines the generation of gamma oscillation currents in the hippocampus, using two-dimensional, 96-site silicon probes and identifies two gamma generators, one in the dentate gyrus and another in the CA3-CA1 regions. Expand
Communication between neocortex and hippocampus during sleep in rodents
TLDR
A robust correlation of neuronal discharges between the somatosensory cortex and hippocampus on both slow and fine time scales in the mouse and rat is shown, suggesting that oscillation-mediated temporal links coordinate specific information transfer between neocortical and hippocampal cell assemblies. Expand
Intracellular features predicted by extracellular recordings in the hippocampus in vivo.
TLDR
A large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral condition, and it is determined that a tetrode in hippocampal area CA1 theoretically should be able to record electrical signals from approximately 1, 000 neurons. Expand
Replay and Time Compression of Recurring Spike Sequences in the Hippocampus
TLDR
It is hypothesized that the endogenously expressed spike sequences during sleep reflect reactivation of the circuitry modified by previous experience and serve to consolidate information in neuronal networks. Expand
The reorganization and reactivation of hippocampal maps predict spatial memory performance
TLDR
This work found that remembering newly learnt goal locations required NMDA receptor–dependent stabilization and enhanced reactivation of goal-related hippocampal assemblies, and suggested that assembly firing patterns in the hippocampus represent the formation and expression of new spatial memory traces. Expand
Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex
TLDR
It is demonstrated that beta oscillations are inappropriately exaggerated, compared with controls, in a brain-state-dependent manner after chronic dopamine loss, and targeting the plastic processes underlying the delayed emergence of pathological Beta oscillations after continuing dopaminergic dysfunction may offer considerable therapeutic promise. Expand
Ensemble Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave–Associated Population Events
TLDR
It is suggested that, in SPW behavioral state, the coherent discharge of a small group of CA3 cells is the primary cause of spiking activity in CA1 pyramidal neurons. Expand
Organization of cell assemblies in the hippocampus
TLDR
Here it is found that the spike times of hippocampal pyramidal cells can be predicted more accurately by using the Spike times of simultaneously recorded neurons in addition to the animals location in space, suggesting that cell assemblies are synchronized at this timescale. Expand
...
1
2
3
4
5
...