J. Crowston

Publications280
h-index46
Citations7,309
Highly Influential Citations283
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Primary open-angle glaucoma
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible blindness worldwide,… Expand
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Definition of glaucoma: clinical and experimental concepts
Glaucoma is a term describing a group of ocular disorders with multi‐factorial etiology united by a clinically characteristic intraocular pressure‐associated optic neuropathy. It is not a single… Expand
  • 275
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Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer’s disease
BackgroundRetinal ganglion cell loss is considered to be a cause of visual impairment in Alzheimer`s patients. Alterations in amyloid precursor protein (APP) processing and amyloid-β (Aβ)… Expand
  • 112
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Oxidative stress and mitochondrial dysfunction in glaucoma.
Mitochondrial dysfunction increases reactive oxygen species (ROS) production and when this overwhelms the cellular antioxidant defences, oxidative stress ensues. Oxidative stress is recognized as a… Expand
  • 199
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Recharacterization of the RGC-5 retinal ganglion cell line.
PURPOSE The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and led to the recharacterization of… Expand
  • 169
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The effect of optic disc diameter on vertical cup to disc ratio percentiles in a population based cohort: the Blue Mountains Eye Study
Objective: The 97.5th percentile for vertical cup to disc ratio (VCDR) has been proposed as a useful tool to assist in the diagnosis of glaucoma in population studies. Previous reports of VCDR… Expand
  • 99
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Optic disk size and glaucoma.
Assessment of optic disk size is an important, but often overlooked, component of the diagnostic evaluation for glaucoma. Measured values of optic disk size vary with the measurement technique… Expand
  • 125
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Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage.
PURPOSE To determine whether oxidative adduct formation or heme oxygenase-1 (HO-1) expression are altered in retinal ganglion cell (RGC) cultures exposed to elevated hydrostatic pressure and in a… Expand
  • 134
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Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data.
PURPOSE To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS Subjects with OAG were… Expand
  • 109
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Neuroprotection in glaucoma
Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells and their axons. Recent evidence suggests that intraocular pressure (IOP) is only one of the many risk factors… Expand
  • 40
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