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An introduction to population genetics theory
An introduction to population genetics theory , An introduction to population genetics theory , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION.
TLDR
This article proposes to examine some of the population consequences of a system of different isoalleles whose frequency in the population is determined by the mutation rate and by random drift, and considers three possibilities: A system of selectively neutral isoallels, a systemof mutually heterotic alleles, and a mixture of heterotic and harmful mutants. Expand
Rates of spontaneous mutation.
TLDR
It is now possible to specify some of the evolutionary forces that shape these diverse mutation rates in broad groups of organisms. Expand
Mutations affecting fitness in Drosophila populations.
Mutation rate and dominance of genes affecting viability in Drosophila melanogaster.
TLDR
That these mutants have a disproportionately large heterozygous effect on total fitness (as well as on the viability component thereof) is shown by the low ratio of the genetic load in equilibrium homozygote to that of new mutant homozygotes. Expand
Some possibilities for measuring selection intensities in man.
  • J. Crow
  • Biology, Medicine
  • Human biology
  • 1 October 1989
TLDR
Consider selection intensity at three levels total, phenotyp , and genotypic, that is, if different genotypes make differential contributions to future genera- Selection can be genetically effective only if it is genotypes, and this sets an upper limit on the amount of genetically effective selection. Expand
AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES.
TLDR
Calculations are presented whereby, using death rates both from Arner's and from two other published studies of consanguineous marriages, the total mutational damage is attempted to measure, by making some assumptions about the manner in which the mutations are expressed, the amount of mutationaldamage actually expressed each generation. Expand
The origins, patterns and implications of human spontaneous mutation
  • J. Crow
  • Biology, Medicine
  • Nature Reviews Genetics
  • 1 October 2000
TLDR
It is suggested that quasi-truncation selection is the principal explanation for how the population can rid itself of a large number of mutations with a relatively low fitness cost. Expand
Evolution in Sexual and Asexual Populations
TLDR
The evolution of diploidy from haploidy confers an immediate reduction in the mutation load by concealment of deleterious recessives, but this advantage is lost once a new equilibrium is reached and the development of diPloidy may be because of an immediate advantage rather than because of any permanent benefit. Expand
Group selection for a polygenic behavioral trait: estimating the degree of population subdivision.
  • J. Crow, K. Aoki
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 October 1984
TLDR
Nei's GST, defined by (F0-F)/(1-F), is a measure of population subdivision that depends mainly on the absolute number of migrants per generation, moves rapidly to near equilibrium, and is independent of the number of alleles. Expand
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