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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared geneticExpand
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Evidence for an Error Monitoring Deficit in Attention Deficit Hyperactivity Disorder
We studied error monitoring in ADHD and control children in a task requiring inhibition of a motor response. The extent of slowing following successful (stopped) and failed (nonstopped) inhibitionExpand
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Is the behavior rating inventory of executive function more strongly associated with measures of impairment or executive function?
The Behavior Rating Inventory of Executive Function (BRIEF) is commonly used in the assessment of children and adolescents presenting with a wide range of concerns. It is unclear, however, whetherExpand
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Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD
A high-resolution analysis of copy number variation in patients with ADHD reveals new gene associations, few de novo mutations, and overlap with genes implicated in other disorders such as autism.Expand
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Analysis of shared heritability in common disorders of the brain
Brainstorming diseases Consistent classification of neuropsychiatric diseases is problematic because it can lead to misunderstanding of etiology. The Brainstorm Consortium examined multipleExpand
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Response Inhibition and ADHD Traits: Correlates and Heritability in a Community Sample
Endophenotypes or intermediate phenotypes are of great interest in neuropsychiatric genetics because of their potential for facilitating gene discovery. We evaluated response inhibition, latency andExpand
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Deficient inhibition as a marker for familial ADHD.
OBJECTIVE The authors investigated whether deficient inhibitory control, as measured by the stop-signal paradigm, delineates a familial subgroup of attention deficit hyperactivity disorder (ADHD). Expand
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Genome-Wide Analysis of Copy Number Variants in Attention Deficit Hyperactivity Disorder: The Role of Rare Variants and Duplications at 15q13.3
Objective: Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has beenExpand
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Disruption at the PTCHD1 Locus on Xp22.11 in Autism Spectrum Disorder and Intellectual Disability
Mutations of the X-linked gene PTCHD1 are associated with autism spectrum disorders and intellectual disability. A Patch in the Fabric of Autism What causes autism? This disabling disorder isExpand
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Association of the glutamate receptor subunit gene GRIN2B with attention‐deficit/hyperactivity disorder
The glutamatergic signaling pathway represents an ideal candidate susceptibility system for attention‐deficit/hyperactivity disorder (ADHD). Disruption of specific N‐methyl‐D‐aspartate‐type glutamateExpand
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