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Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
TLDR
Functional magnetic resonance imaging in healthy volunteers found that Δ-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Δ- 9- THC. Expand
Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
TLDR
The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a similar response as the HC, and no significant differences were observed between CBD and HC in SSPS-N scores or in the cognitive impairment, discomfort, and alert factors of VAMS. Expand
Neuroimaging in social anxiety disorder: A systematic review of the literature
TLDR
The present review indicates that neuroimaging has contributed to a better understanding of the neurobiology of SAD, and the predominance of evidence implicating the amygdala strengthens the notion that it plays a crucial role in the pathophysiology of S AD. Expand
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report.
OBJECTIVES Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore haveExpand
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network
TLDR
The notion that the altered state of consciousness induced by Ayahuasca, like those induced by psilocybin (another serotonergic psychedelic), meditation and sleep, is linked to the modulation of the activity and the connectivity of the DMN is supported. Expand
Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study
TLDR
The results suggest that ayahuasca may have fast-acting and sustained antidepressive properties and should be replicated in randomized, double-blind, placebo-controlled trials. Expand
Safety and side effects of cannabidiol, a Cannabis sativa constituent.
TLDR
In vivo and in vitro reports of CBD administration across a wide range of concentrations suggest controlled CBD may be safe in humans and animals, but further studies are needed to clarify reported in vitro and in vivo side effects. Expand
Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.
TLDR
The results of two studies on healthy volunteers using perception of binocular depth inversion and ketamine-induced psychotic symptoms supported the proposal of the antipsychotic-like properties of CBD and confirmed that this cannabinoid can be a safe and well-tolerated alternative treatment for schizophrenia. Expand
Alcohol Use Disorders Identification Test (AUDIT): an updated systematic review of psychometric properties
Alcohol Use Disorders Identification Test (AUDIT) is an instrument used to screen for alcohol-related problems. It has been increasingly used in many different countries in both the originalExpand
Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder
TLDR
The results may provide a valuable basis for future studies combining morphometric, functional and anatomical data in the search for a comprehensive understanding of the neural circuitry underlying SAD. Expand
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