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Inhibition of acute nociceptive responses in rats after i.c.v. injection of Thr6‐bradykinin, isolated from the venom of the social wasp, Polybia occidentalis
In this work, a neuroactive peptide from the venom of the neotropical wasp Polybia occidentalis was isolated and its anti‐nociceptive effects were characterized in well‐established pain inductionExpand
Neurochemical Characterization of a Neuroprotective Compound from Parawixia bistriata Spider Venom That Inhibits Synaptosomal Uptake of GABA and Glycine
According to experimental glaucoma data in rat retina, FrPbAII is able to cross the blood-retina barrier and promote effective protection of retinal layers submitted to ischemic conditions and is selective for GABA and glycine transporters. Expand
Mutation in a calpain-like protease affects the posttranslational mannosylation of phosphatases in Aspergillus nidulans.
A defect in the posttranslational mannosylation of proteins could be the consequence of mutations in the palB gene, which encodes for a nuclear calpain-like protease that may have specific functions in the processing of transcription factor(s) similar to its homolog, RIM13, in Saccharomyces cereviseae. Expand
Glutamate Release in Experimental Ischaemia of the Retina: An Approach Using Microdialysis
A rabbit eye model of neural ischaemia is described that uses an increased pressure in the anterior eye chamber to block the capillary supply to the retina and damage was prevented by keta‐mine applied locally via a superfusion needle, suggesting that glutamate released during ischaemic, and particularly during reperfusion, was responsible for cell death. Expand
Pharmacological and Biochemical Aspects of GABAergic Neurotransmission: Pathological and Neuropsychobiological Relationships
The present review will be focused on the pharmacology and biochemistry of the GABA metabolism, GABA receptors and transporters, and the pathological and psychobiological implications related to GABAergic neurotransmission. Expand
Indicators of oxidative injury and alterations of the cell membrane in the skeletal muscle of rats submitted to ischemia and reperfusion.
After a total ischemia duration of 3 h there were signs of damage to the phospholipid membrane of the rat skeletal muscle, as demonstrated by the elevation of OPS and the few or no oxidative changes in the cell. Expand
The inflammatory stimulus of a natural latex biomembrane improves healing in mice.
NLB significantly induced the inflammatory phase of healing mediated by oxidative stress, which appeared to influence the subsequent phases such as angiogenesis (with low expression of VEGF) and fibroplasia (independent of TGF-β1) without influencing collagenesis. Expand
Angiogenic properties of natural rubber latex biomembranes and the serum fraction of Hevea brasiliensis
The angiogenic properties of natural rubber were evaluated in this work. We have used the chick chorioallantoic membrane assay (CAM) as a model to investigate the influence of the heating onExpand
Actions of Ptychodiscus brevis Red Tide Toxin on Metabolic and Transmitter‐Releasing Properties of Synaptosomes
The toxin at 40 ng/ml caused acetylcholine release from guinea pig ileum, which is consistent with the proposed depolarising action for the toxin, and verapamil was likely to be acting as a Na+ channel blocker in this instance. Expand
Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol
It was concluded that different neuronal circuitry in the hippocampal formation are modulated, at least partially by nigral GABAergic mechanisms. Expand