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Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli.
The SOS response in UV-irradiated Escherichia coli includes the upregulation of several dozen genes that are negatively regulated by the LexA repressor. Using DNA microarrays containing amplified DNAExpand
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RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli
Abstract The accurate recovery of replication following DNA damage and repair is critical for the maintenance of genomic integrity. In Escherichia coli, the recovery of replication followingExpand
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recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli.
Escherichia coli containing a mutation in recF are hypersensitive to UV. However, they exhibit normal levels of conjugational or transductional recombination unless the major pathway (recBC) isExpand
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DNA Damage-Induced Replication Fork Regression and Processing in Escherichia coli
DNA lesions that block replication are a primary cause of rearrangements, mutations, and lethality in all cells. After ultraviolet (UV)-induced DNA damage in Escherichia coli, replication recoveryExpand
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Structural conservation of RecF and Rad50: implications for DNA recognition and RecF function
RecF, together with RecO and RecR, belongs to a ubiquitous group of recombination mediators (RMs) that includes eukaryotic proteins such as Rad52 and BRCA2. RMs help maintain genome stability in theExpand
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RecA-dependent recovery of arrested DNA replication forks.
DNA damage encountered during the cellular process of chromosomal replication can disrupt the replication machinery and result in mutagenesis or lethality. The RecA protein of Escherichia coli isExpand
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Recovery of DNA replication in UV-irradiated Escherichia coli requires both excision repair and recF protein function.
After UV doses that disrupt DNA replication, the recovery of replication at replication forks in Escherichia coli requires a functional copy of the recF gene. In recF mutants, replication fails toExpand
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Completion of DNA replication in Escherichia coli
Significance All phases of DNA replication are tightly regulated to ensure that daughter cells inherit a precise copy of the genomic DNA. Although the mechanisms regulating initiation and elongationExpand
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Requirement for Uracil-DNA Glycosylase during the Transition to Late-Phase Cytomegalovirus DNA Replication
ABSTRACT Cytomegalovirus gene UL114, a homolog of mammalian uracil-DNA glycosylase (UNG), is required for efficient viral DNA replication. In quiescent fibroblasts, UNG mutant virus replication isExpand
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Nucleotide excision repair or polymerase V-mediated lesion bypass can act to restore UV-arrested replication forks in Escherichia coli.
Nucleotide excision repair and translesion DNA synthesis are two processes that operate at arrested replication forks to reduce the frequency of recombination and promote cell survival followingExpand
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