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Chagas disease: a new worldwide challenge
Endemic Chagas disease began as a neglected disease of poor, rural and forgotten populations is a new worldwide challenge, say Jose Rodrigues Coura and Pedro Albajar Vinas. Expand
Emerging Chagas disease in Amazonian Brazil.
The status of Chagas disease in Amazonian Brazil, including known reservoirs and vectors, and the genetic diversity of T. cruzi is reviewed, indicating that the disease may be emerging as a wider public health problem in the region. Expand
Epidemiology, control and surveillance of Chagas disease: 100 years after its discovery.
Control of Chagas disease must be undertaken by interrupting its transmission by vectors and blood transfusions, improving housing and areas surrounding dwellings, providing sanitation education for exposed populations and treating acute and recently infected chronic cases. Expand
Chagas disease: what is known and what is needed--a background article.
  • J. Coura
  • Biology, Medicine
  • Memorias do Instituto Oswaldo Cruz
  • 30 October 2007
This article presents the ten top Chagas disease needs for the near future, characterized by an acute phase with or without symptoms, and with entry point signs (inoculation chagoma or Romaña's sign), fever, adenomegaly, hepatosplenomeGaly, and evident parasitemia. Expand
Immunoblot assay using excreted-secreted antigens of Trypanosoma cruzi in serodiagnosis of congenital, acute, and chronic Chagas' disease
The TESA blot seems to be useful as a sensitive and specific diagnostic assay in cases of suspected acute or congenital T. cruzi infection and as a general confirmatory test for conventional Chagas' disease serology. Expand
Chagas disease: 100 years after its discovery. A systemic review.
There is great regional variation in the morbidity caused by Chagas disease: severe cardiac or digestive forms may occur in 10-50%, and indeterminate forms in the remaining, asymptomatic cases. Expand
A mini-exon multiplex polymerase chain reaction to distinguish the major groups of Trypanosoma cruzi and T. rangeli in the Brazilian Amazon.
The chagasdisease-like symptoms seen in patients with central giant cell granuloma are similar to those of other central nervous system diseases and are likely to be passed on through the immune system through various routes, including contact chemoreception, EMT and ‘cell reprograming’. Expand
Brazilian isolates of Trypanosoma cruzi from humans and triatomines classified into two lineages using mini-exon and ribosomal RNA sequences.
Traditional molecular and biochemical methods, such as schizodeme analysis, karyotyping, DNA fingerprinting, and enzyme electrophoretic profiles, have shown a large variability among TrypanosomaExpand
Molecular epidemiology of American trypanosomiasis in Brazil based on dimorphisms of rRNA and mini-exon gene sequences.
Molecular typing of human parasite isolates from three well-characterised endemic regions of Chagas disease and from Amazonas State, where T. cruzi is enzootic, suggests that in some endemic areas in Brazil there is a preferential linkage between both cycles mediated by lineage-1 stocks. Expand
Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission.
These data are important in understanding the complexity of the transmission cycles, genetic structure, and evolutionary history of T. cruzi populations circulating in Amazonia, and they contribute to both the unravelling of human infection routes and the pathological peculiarities of Chagas disease in this region. Expand