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Alterations in DNA methylation may play a variety of roles in carcinogenesis
There is considerable interest in the role that DNA methylation (5-methylcytosine [5MeC] content of DNA) plays in both normal development (Razin and Kafri, 1994) and carcinogenesis (Laird et al.,… Expand
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.
- J. Counts, J. I. Sarmiento, M. L. Harbison, J. Downing, R. McClain, J. L. Goodman
- Medicine, Biology
Our laboratory is testing the hypothesis that hypomethylation of DNA [a decreased content of 5-methylcytosine (5MeC) compared with cytosine] facilitates aberrant oncogene expression involved in… Expand
Comparison of effect of tumor promoter treatments on DNA methylation status and gene expression in B6C3F1 and C57BL/6 mouse liver and in B6C3F1 mouse liver tumors.
The effects of different liver tumor-promoting treatments (i.e., a choline-devoid, methionine-deficient (CMD) diet, phenobarbital (PB), or both) on Ha-ras and raf methylation status and expression… Expand
Hypomethylation of DNA: a possible epigenetic mechanism involved in tumor promotion.
The overall objective of our research is to discern mechanisms that can facilitate the aberrant expression of oncogenes involved in carcinogenesis. We are testing the hypothesis that hypomethylation… Expand
Hypomethylation of DNA: an epigenetic mechanism involved in tumor promotion.
Keywords: Carcinogenesis; Cell proliferation; DNA methylation; epigenetic; hypomethylation; promotion; risk assessment
Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion.
There is an abundant amount of information on the mechanisms of action of genotoxic chemicals that act as carcinogens and the role that mutations play in carcinogenesis. However, carcinogenesis is… Expand
Principles underlying dose selection for, and extrapolation from, the carcinogen bioassay: dose influences mechanism.
The purpose of the bioassay is not to simply find chemicals that can be labeled as carcinogens. On the contrary, the overall goal is to provide a reasonable assessment of the possible hazard that a… Expand
Hypomethylation of DNA: a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis.
DNA methylation (i.e., the 5-methylcytosin content of DNA) plays a role in the regulation of gene activity. There is a persuasive body of evidence indicating that differential methylation of DNA… Expand
5‐methylcytosine is present in the 5′ flanking region of ha‐ras in mouse liver and increases with ageing
- J. Counts, J. M. Kaznowski, R. McClain, J. Goodman
- Biology, Medicine
- International journal of cancer
- 29 July 1997
Modifications to DNA‐5‐methylcytosine (5MeC) content (i.e., alterations in the level of 5MeC) constitute epigenetic events. In general, hypomethylation of a gene is necessary but not sufficient for… Expand
Hypomethylation of DNA: An epigenetic mechanism that can facilitate the aberrant oncogene expression involved in liver carcinogenesis
Publisher Summary Hypomethylation may be a mechanism underlying the role of cell proliferation in carcinogenesis, and hypomethylation could possibly result from an enzymatic replacement of 5MeC with… Expand