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Deubiquitylases from genes to organism.
- M. J. Clague, I. Barsukov, J. Coulson, Han Liu, D. Rigden, S. Urbé
- BiologyPhysiological reviews
- 1 July 2013
A comprehensive analysis of the complement of human DUBs is provided, indicating structural motifs, typical cellular copy numbers, and tissue expression profiles, and the means by which specificity is achieved and how DUB activity may be regulated.
Cellular functions of the DUBs
The cellular functions of DUBs are discussed, such as their role in governing membrane traffic and protein quality control, and two key signalling pathways – the Wnt and transforming growth factor β (TGF-β) pathways, for which dynamic ubiquitylation has emerged as a key regulator.
Emerging roles of deubiquitinases in cancer‐associated pathways
The current literature that associates DUBs with cancer is reviewed, their suitability as drug targets of the future is discussed and they can negatively regulate ubiquitin‐dependent signalling cascades such as the NF‐κB activation pathway.
A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker.
It is proposed that the encoded isoform may antagonize repression of the vasopressin promoter and other "neuronal" genes with neuron-restrictive silencer elements in SCLCs and may be a key early factor in defining the neuroendocrine phenotype of these tumors.
Transcriptional Regulation: Cancer, Neurons and the REST
- J. Coulson
- BiologyCurrent Biology
- 6 September 2005
Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development
It is shown that BAP1 loss is correlated with upregulation of several genes associated with suppressive immune responses, some of which build an immune suppressive axis, including HLA‐DR, CD38, and CD74, which will further enable functional validation of detected biomarkers and the development of focused immunotherapeutic approaches.
Cross-talk between hypoxic and circadian pathways: cooperative roles for hypoxia-inducible factor 1α and CLOCK in transcriptional activation of the vasopressin gene
SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer
- A. Moss, G. Jacobson, L. Walker, N. Blake, E. Marshall, J. Coulson
- Biology, MedicineClinical Cancer Research
- 1 January 2009
In peripheral blood of lung cancer patients and cancer-free individuals, it was found that SCG3 was more tumor-specific and more sensitive than other chromogranin transcripts as a biomarker of circulating tumor cells.
Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells.
Proteome and phospho-proteomic analysis of isogenic 786-O RCC (±VHL) cells are combined to compare signatures that reflect hypoxia and/or loss of VHL, indicating an unusual mechanism of control for CA2 expression that reflects enhanced activity of the NFκB pathway, which is associated with loss ofVHL.
Studies on the expression of endothelin, its receptor subtypes, and converting enzymes in lung cancer and in human bronchial epithelium.
- S. Ahmed, J. Thompson, J. Coulson, P. Woll
- Biology, MedicineAmerican journal of respiratory cell and…
- 1 April 2000
It is proposed that endothelin (ET)-1 may act as a paracrine growth factor for surrounding epithelial and endothelial cells via alternative pathways, promoting angiogenesis and stromal growth.