J. Couchman

Publications288
h-index77
Citations18,251
Highly Influential Citations569
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Proteoglycans and Sulfated Glycosaminoglycans
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RhoGDI: multiple functions in the regulation of Rho family GTPase activities.
TLDR
Results point to a wider role for RhoGDI than initially perceived, making it a binding partner that can tightly control Rho GTPases, but which also allows them to reach their full spectrum of activities.
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Transmembrane signaling proteoglycans.
  • J. Couchman
  • Biology
    Annual review of cell and developmental biology
  • 6 October 2010
TLDR
Work with model systems in vivo and in vitro reveals roles in growth, adhesion, migration, and metabolism in transmembrane proteoglycans, and a wide range of phenotypes for the core proteins has been obtained in mouse knockout experiments.
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Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions.
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Syndecans: proteoglycan regulators of cell-surface microdomains?
  • J. Couchman
  • Biology, Chemistry
    Nature Reviews Molecular Cell Biology
  • 1 December 2003
TLDR
New structural features of syndecan cytoplasmic domains have been described, together with new insights into signalling across the cell membrane that might involve the concentration of ligands in membrane microdomains.
View on Nature
Proteoglycans in health and disease: the multiple roles of syndecan shedding
TLDR
Recent research into the shedding of syndecan cell‐surface proteoglycans and its physiological relevance are assessed.
View on Wiley
Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues
TLDR
It is demonstrated that chondroitin sulphates exhibit remarkable connective tissue specificity and furthermore there is evidence that some proteoglycans may predominantly carry only one type of chondDetroitin sulphate chain.
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EphB/Syndecan-2 Signaling in Dendritic Spine Morphogenesis
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Protein kinase C involvement in focal adhesion formation.
TLDR
It is shown here that the kinase inhibitors H7 and HA1004 reduce focal adhesion and stress fiber formation in response to fibronectin in a dose-dependent manner, and that activators of protein kinase C can promote their formation under conditions where they do not normally form.
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The Rho kinases I and II regulate different aspects of myosin II activity
TLDR
Analysis of fibroblast adhesion to fibronectin revealed that although ROCK II was more abundant, its activity was always lower than ROCK I, and endogenous ROCKs are distinctly regulated and in turn are involved with different myosin compartments.
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