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Bacterial biofilms: a common cause of persistent infections.
TLDR
Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Bacterial biofilms: from the Natural environment to infectious diseases
TLDR
It is evident that biofilm formation is an ancient and integral component of the prokaryotic life cycle, and is a key factor for survival in diverse environments.
The involvement of cell-to-cell signals in the development of a bacterial biofilm.
TLDR
The involvement of an intercellular signal molecule in the development of Pseudomonas aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aerug inosaBiofilms are a persistent problem.
Biofilms as complex differentiated communities.
TLDR
It is submitted that complex cell-cell interactions within prokaryotic communities are an ancient characteristic, the development of which was facilitated by the localization of cells at surfaces, which may have provided the protective niche in which attached cells could create a localized homeostatic environment.
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
TLDR
It is understood that biofilms are universal, occurring in aquatic and industrial water systems as well as a large number of environments and medical devices relevant for public health, and that treatments may be based on inhibition of genes involved in cell attachment and biofilm formation.
Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm
TLDR
The results demonstrate that P. aeruginosa displays multiple phenotypes during biofilm development and that knowledge of stage-specific physiology may be important in detecting and controlling biofilm growth.
Microbial biofilms.
TLDR
This work has discovered that adhesion triggers the expression of a sigma factor that derepresses a large number of genes so that biofilm cells are clearly phenotypically distinct from their planktonic counterparts.
Biofilms, the customized microniche
At its 1993 annual meeting, the American Society for Microbiology deemed the biofilm mode of growth to be a concept worthy of an extraordinary 4-day colloquium consisting of 52 lectures from invited
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