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Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
TLDR
People with atopic asthma are not at greater risk of rhinovirus infection than healthy individuals but suffer from more frequent LRT infections and have more severe and longer-lasting LRT symptoms. Expand
IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury.
TLDR
IL-13 has protective effects in hyperoxic acute lung injury, and it is demonstrated that IL-13, alone and in combination with 100% (2), stimulates pulmonary VEGF accumulation, that this stimulation is isoform-specific, and that the protective effects of IL- 13 are mediated, in part, by VEGf. Expand
Quantitative Validation and Comparison of Multiplex Cytokine Kits
TLDR
Luminex kits were found to be highly reproducible and reliable; however, CBA kits were not due to aberrant standards, but correlations with ELISA were good for all technologies. Expand
Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells.
TLDR
The present review will begin by describing the current understanding of inflammatory cell involvement in the disease process, and then focus on the possible role of subsets of regulatory and helper T-cells in COPD. Expand
Altered effector function of peripheral cytotoxic cells in COPD
TLDR
It is shown that the relative numbers of peripheral blood NK ( CD56+CD3-) and NKT-like (CD56+ CD3+) cells in COPD subjects are reduced and that their cytotoxic effector function is defective. Expand
Killer cells in chronic obstructive pulmonary disease.
TLDR
The focus of the present review is directed towards the role of CD8(+) T-lymphocytes, NK (natural killer) cells and NKT cells (NK T-cells) in COPD, which could all play an important part in the pathogenesis of COPD. Expand
MMP-9 protein level does not reflect overall MMP activity in the airways of patients with COPD.
TLDR
The results suggest that MMP-9 levels may not reflect the overall MMP activity in the airways of patients with COPD suggesting a complex relationship between M MP-9 protein and activity. Expand
Future research into the treatment of vitiligo: where should our priorities lie? Results of the vitiligo priority setting partnership
TLDR
This work has shown that the research evidence for treatment of vitiligo is poor, making it difficult to make firm recommendations for clinical practice. Expand
Standards of care for occupational asthma
TLDR
The intent of this article is not to document the entire current evidence base related to occupational asthma, as the British Occupational Health Research Foundation (BOHRF) recently completed such an evidence review. Expand
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