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Neuroanatomical hypothesis of panic disorder, revised.
Medications, particularly those that influence the serotonin system, are hypothesized to desensitize the fear network from the level of the amygdala through its projects to the hypothalamus and the brainstem, and effective psychosocial treatments may also reduce contextual fear and cognitive misattributions. Expand
Neuroanatomical Hypothesis of Panic Disorder, Revised
Objective: In a 1989 article, the authors provided a hypothesis for the neuroanatomical basis of panic disorder that attempted to explain why both medication and cognitive behavioral psychotherapyExpand
Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood
Grown nonhuman primates who were exposed as infants to adverse early rearing conditions were studied to determine if long-term alterations of CRF neuronal systems had occurred following the early stressor. Expand
Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates
It is demonstrated that ECS is capable of inducing neurogenesis in the nonhuman primate hippocampus and supports the possibility that antidepressant interventions produce similar alterations in the human brain. Expand
Anxiogenic effects of CO2 and hyperventilation in patients with panic disorder.
Panic patients were clearly more sensitive to the anxiogenic effects of CO2 than comparison subjects, and CO2 was a more potent anxiolysis stimulus than room-air hyperventilation. Expand
Depression and anxiety in urban hemodialysis patients.
The findings of both concurrent and isolated anxiety suggest that the prevalence of psychopathology in patients with ESRD might be higher than previously expected, and the disorders may need to be treated independently. Expand
Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxiety
Neuroanatomical pathways that may be important in the antianxiety effect of the SSRIs are outlined and discussed, followed by a review of the clinical evidence supporting the efficacy of this class of medications in the treatment of anxiety disorders. Expand
Respiratory psychophysiology of panic disorder: three respiratory challenges in 98 subjects.
The findings confirm the greater behavioral and physiological sensitivity of patients with panic disorder to CO2 inhalation and identify a series of respiratory abnormalities that were confirmed during three respiratory challenges that used improved methodology. Expand
Anxiety disorders in adults treated by hemodialysis: a single-center study.
The finding that anxiety disorders negatively impact on QOL and are not merely manifestations of depression in patients with ESRD emphasizes the importance of accurate diagnosis and effective treatment. Expand
Psychiatric symptoms in adolescence as predictors of obesity in early adulthood: a longitudinal study.
OBJECTIVES This study examined the longitudinal relationship between psychopathology and obesity in young adulthood. METHODS More than 700 youth in a population-based sample were psychiatricallyExpand