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GLC determination of plasma levels of warfarin.
TLDR
The method is of sufficient sensitivity to determine plasma levels in humans after single doses (20 mg) of warfarin (sensitivity of 0.25 μg/ml) and the methyl derivatives ofwarfarin and the internal standard give sharp, well-separated, symmetrical peaks.
Identification of phase-I and phase-II metabolites of fluphenazine in rat bile. Intact glucuronide and sulfate conjugates.
TLDR
This report provides the first direct evidence of the presence of intact phase-II metabolites of FLU in rat bile.
Radioimmunoassay for psychotropic drugs I: synthesis and properties of haptens for chlorpromazine.
For the development of radioimmunoassay procedures for chlorpromazine and its active metabolites, three chlorpromazine haptens, 7-(or 8-)(3-carboxypropionyl)chlorpromazine,
High-performance liquid chromatographic assay for nanogram determination of chlorpromazine and its comparison with a radioimmunoassay.
TLDR
The procedure is capable of determining 1 ng of chlorpromazine/ml and is adequate for following plasma concentration-time profiles after 7-mg single intravenous doses and is compared with those obtained by a previously reported radioimmunoassay specific for chlor Promazine and N-desmethylchlorpromazine.
Therapeutic monitoring of chlorpromazine II: Pitfalls in whole blood analysis.
TLDR
It is found that chlorpromazine N-oxide resides almost entirely in the plasma with only a small portion distributed into the red cells, and alkaline extraction methods must be avoided in the analysis of chlor Promazine in the red cell fraction.
alpha-Methyldopamine, a key intermediate in the metabolic disposition of 3,4-methylenedioxyamphetamine in vivo in dog and monkey.
TLDR
The phenolic metabolites in both species were present free and as glucuronide and/or sulfate conjugates, whereas the dog urine had 3-methoxy-4-hydroxybenzoic acid present as a conjugate other than glucuronides and sulfate.
Kinetics of oral trifluoperazine disposition in man.
TLDR
The disposition of trifluoperazine was studied in five healthy volunteers following oral administration of a 5 mg tablet and the area under the plasma concentration-time curve differed widely between subjects suggesting large individual differences in the extent of presystemic TFP elimination.
The identification of urinary metabolites of doxepin in patients.
TLDR
The tentative identification of this hydrated metabolite lends significant support to a possible mechanism responsible for the enrichment of cis-N-desmethyldoxepin over time in plasma.
Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine
TLDR
The data suggest that CYP2D6 is involved in the metabolism of chlorpromazine to 7-hydroxychlorpromazine, however, genetic polymorphism in this metabolic process did not play a dominant role in accounting for the extremely large interindividual variations in plasma concentrations encountered with this drug.
Stereoselective pharmacokinetics of doxepin isomers
TLDR
Results for total doxepin showed wide intersubject variation in all pharmacokinetic parameters except tmax and Cmax and the areas under the plasma concentration versus time curves (AUC) of cis-N-desmethyldoxepin were significantly higher than those of the corresponding trans-isomer.
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