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Iron, brain ageing and neurodegenerative disorders
TLDR
By studying the accumulation and cellular distribution of iron during ageing, this work should be able to increase the understanding of these neurodegenerative disorders and develop new therapeutic strategies.
Iron status and neural functioning.
TLDR
Future studies with more specific measures of neurodevelopment in iron-deficient human infants, and animal models, will allow investigators to more clearly define causal roles of brain iron in neural development and functioning.
Long-lasting neural and behavioral effects of iron deficiency in infancy.
TLDR
Evidence of long-term effects of iron deficiency in infancy and follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences.
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat
TLDR
The results indicate that DMT1 and MTP1 are involved in brain iron transport and this involvement is regionally and cellularly specific.
Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier
TLDR
The perfusion of rat brain with 125I‐transferrin resulted in a receptor‐mediated uptake of transferrin into the endothelium of the blood‐brain barrier followed by its detecation in the brain, suggesting that the brain may derive its iron through the transcytosis of iron‐loaded transferrin across the brain microvasculature.
Oligodendrocytes and myelination: The role of iron
TLDR
This review gives a comprehensive overview of the existing literature on role of iron in oligodendrocytes and the mechanisms of iron acquisition and intracellular handling to identify effective therapies for dysmyelinating disorders.
A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains
TLDR
A disruption in brain iron homeostasis in Alzheimer's disease is strongly suggested as demonstrated by alterations in the normal cellular distribution of iron and the proteins responsible for iron regulation.
Relationship of iron to oligodendrocytes and myelination.
TLDR
The many known phenomena that decrease oligodendrocyte survival and/or myelin production may mediate their effect through a final common pathway that involves disruptions in iron availability or intracellular management of iron.
Characterization of a novel brain‐derived microglial cell line isolated from neonatal rat brain
TLDR
The results of this study indicate that HAPI cells possess the characteristics of microglia/brain macrophages, providing an alternative cell culture model for the study of microGlia/macrophage lineage.
Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome
TLDR
RLS may not be rooted in pathologies associated with traditional neurodegenerative processes but may be a functional disorder resulting from impaired iron acquisition by the neuromelanin cells in RLS.
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