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Iron, brain ageing and neurodegenerative disorders
There is increasing evidence that iron is involved in the mechanisms that underlie many neurodegenerative diseases. Conditions such as neuroferritinopathy and Friedreich ataxia are associated withExpand
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Iron status and neural functioning.
Iron deficiency in early life is associated with delayed development as assessed by a number of clinical trials using similar global scales of development; this poor development during infancyExpand
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Long-lasting neural and behavioral effects of iron deficiency in infancy.
Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age toExpand
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Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat
Iron accumulation in the brain occurs in a number of neurodegenerative diseases. Two new iron transport proteins have been identified that may help elucidate the mechanism of abnormal ironExpand
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Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase.
OBJECTIVE To evaluate the in vivo therapeutic efficacy of N-iminoethyl-L-lysine (L-NIL), a selective inhibitor of inducible nitric oxide synthase (iNOS), on the progression of lesions in anExpand
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Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (*)
Random high throughput sequencing of a human osteoclast cDNA library was employed to identify novel osteoclast-expressed genes. Of the 5475 ESTs obtained, approximately 4% encoded cathepsin K, aExpand
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Characterization of a novel brain‐derived microglial cell line isolated from neonatal rat brain
We observed highly aggressively proliferating immortalized (HAPI) cells growing in cultures that had been enriched for microglia. The cells were initially obtained from mixed glial cultures preparedExpand
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Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome
Objective: To assess neuropathology in individuals with restless legs syndrome (RLS). Methods: A standard neuropathologic evaluation was performed on seven brains from individuals who had beenExpand
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Oligodendrocytes and myelination: The role of iron
Iron is an essential trophic factor that is required for oxygen consumption and ATP production. Thus it plays a key role in vital cell functions. Although the brain has a relatively high rate ofExpand
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Transferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions
Abstract: Oxidant‐mediated damage is suspected to be involved in the pathogenesis of several neurodegenerative disorders. Iron promotes conversion of hydrogen peroxide to hydroxyl radical and, thus,Expand
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