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Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study.
TLDR
An aggressive smoking intervention program significantly reduces the age-related decline in FEV1 in middle-aged smokers with mild airways obstruction and use of an inhaled anticholinergic bronchodilator results in a relatively small improvement that appears to be reversed after the drug is discontinued. Expand
Azithromycin for prevention of exacerbations of COPD.
TLDR
Among selected subjects with COPD, azithromycin taken daily for 1 year, when added to usual treatment, decreased the frequency of exacerbations and improved quality of life but caused hearing decrements in a small percentage of subjects. Expand
Smoking and lung function of Lung Health Study participants after 11 years.
TLDR
Differences in lung function between treatment groups persisted; smoking intervention participants had less decline in FEV(1) than usual care participants and smoking habits by original LHS treatment groups tended to converge. Expand
Leisure-time physical activity levels and risk of coronary heart disease and death. The Multiple Risk Factor Intervention Trial.
TLDR
It is concluded that LTPA has a modest inverse relation to CHD and overall mortality in middle-aged men at high risk for CHD. Expand
A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction
TLDR
A strong mechanistic link among early nicotine exposure, common CHRNA5-A3-B4 haplotypes, and adult nicotine addiction in three independent populations of European origins is established and reinforces the importance of preventing early exposure to tobacco through public health policies. Expand
Hospitalizations and mortality in the Lung Health Study.
TLDR
When all participants were considered and smoking status considered as a time-dependent covariate, smoking cessation was associated with significant reductions in fatal or nonfatal cardiovascular disease and coronary artery disease. Expand
Effects of Smoking Intervention and the Use of an Inhaled Anticholinergic Bronchodilator on the Rate of Decline of FEV1: The Lung Health Study
TLDR
An aggressive smoking intervention program significantly reduces the age-related decline in FEV 1 in middle-aged smokers with mild airways obstruction and use of an inhaled anticholinergic bronchodilator results in a relatively small improvement inFEV 1 that appears to be reversed after the drug is discontinued. Expand
C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease
TLDR
CRP measurements provide incremental prognostic information beyond that achieved by traditional markers of prognosis in patients with mild to moderate COPD, and may enable more accurate detection of patients at a high risk of mortality. Expand
Simvastatin for the prevention of exacerbations in moderate-to-severe COPD.
TLDR
Simvastatin at a daily dose of 40 mg did not affect exacerbation rates or the time to a first exacerbation in patients with COPD who were at high risk for exacerbations. Expand
Roux-en-Y gastric bypass for diabetes (the Diabetes Surgery Study): 2-year outcomes of a 5-year, randomised, controlled trial.
TLDR
The addition of gastric bypass to lifestyle and medical management in patients with type 2 diabetes improved diabetes control, but adverse events and nutritional deficiencies were more frequent. Expand
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