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Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
BackgroundAutism comprises a spectrum of behavioral and cognitive disturbances of childhood development and is known to be highly heritable. Although numerous approaches have been used to identifyExpand
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The role of Bisphenol A in shaping the brain, epigenome and behavior
Bisphenol A (BPA) is a xenoestrogen that was first synthesized in 1891. Its estrogenic properties were discovered in 1930, and shortly after that chemists identified its usefulness in the productionExpand
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Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression.
Bisphenol A (BPA) is a plasticizer and an endocrine-disrupting chemical. It is present in a variety of products used daily including food containers, paper, and dental sealants and is now widelyExpand
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Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain
Significance Although understanding the precise nature of oxytocin’s influence on complex human social behavior has proven difficult, increasing evidence points to an anxiolytic effect. We use anExpand
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DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli
Oxytocin and its receptor (OXTR) play an important role in a variety of social perceptual and affiliative processes. Individual variability in social information processing likely has a strongExpand
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Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy
Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studiesExpand
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Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the Pgc-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring
Abnormal conditions during early development adversely affect later health. We investigated whether maternal exercise could protect offspring from adverse effects of a maternal high-fat diet (HFD)Expand
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GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease
The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up theExpand
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Sex and diagnosis specific associations between DNA methylation of the oxytocin receptor gene with emotion processing and temporal-limbic and prefrontal brain volumes in psychotic disorders.
BACKGROUND The oxytocin (OT) system, including receptor epigenetic mechanisms, has been shown to influence emotion processing, especially in females. Whether OT receptor (OXTR) epigenetic alterationsExpand
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Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others
Recent research indicates that the neuropeptide oxytocin and the gene for the oxytocin receptor (OXTR) have been implicated in the modulation of various social behaviors, including those related toExpand
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