• Publications
  • Influence
The evolutionary fate and consequences of duplicate genes.
TLDR
Although duplicate genes may only rarely evolve new functions, the stochastic silencing of such genes may play a significant role in the passive origin of new species. Expand
The Origins of Genome Complexity
TLDR
It is argued that many of these modifications emerged passively in response to the long-term population-size reductions that accompanied increases in organism size, and provided novel substrates for the secondary evolution of phenotypic complexity by natural selection. Expand
Mutation Accumulation and the Extinction of Small Populations
TLDR
Application of empirical estimates of the properties of spontaneous deleterious mutations leads to the conclusion that populations with effective sizes smaller than 100 are highly vulnerable to extinction via a mutational meltdown on timescales of approximately 100 generations. Expand
The evolutionary demography of duplicate genes
  • M. Lynch, J. Conery
  • Biology, Medicine
  • Journal of Structural and Functional Genomics
  • 2004
TLDR
The origin of a new function appears to be a very rare fate for a duplicate gene through the generation of microchromosomal rearrangements through reciprocal silencing of alternative copies, which can lead to the passive origin of post-zygotic reproductive barriers in descendant lineages of incipient species. Expand
Automated identification of conserved synteny after whole-genome duplication.
TLDR
An automated system to identify conserved syntenic regions in a primary genome using as outgroup a genome that diverged from the investigated lineage before a whole-genome duplication event is developed and the product, the Synteny Database, allows a user to examine fully or partially assembled genomes. Expand
The and/or process model for parallel interpretation of logic programs
TLDR
This dissertation introduces the AND/OR Process Model, a method for interpretation by a system of asynchronous, independent processes that communicate only by messages that makes it possible to exploit two distinct forms of parallelism. Expand
MUTATIONAL MELTDOWNS IN SEXUAL POPULATIONS
TLDR
Results based on computer simulations and supported by analytical approximations indicate that mutation accumulation in small, random‐mating monoecious populations can lead to mean extinction times less than a few hundred to a few thousand generations. Expand
Parallel Execution of Logic Programs
TLDR
The author explains how the AND/OR Process Model, a model for parallelism in Logic Programs, and the Interpreter, a programming language based on Oracle, changed the way that people thought about and understood parallelism. Expand
Parallel interpretation of logic programs
TLDR
An abstract model that exploits the parallelism due to nondeterministic choices in a logic program and a working interpreter based on this model is described, along with variants of the basic model that are capable of exploiting other sources of parallelism. Expand
A Neural Network Model of Chemotaxis Predicts Functions of Synaptic Connections in the Nematode Caenorhabditis elegans
TLDR
Common patterns of connectivity between the model and biological networks suggest new functions for previously identified connections in the C. elegans nervous system, and it is shown that feedback regulates the latency between sensory input and behavior. Expand
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