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Acenocoumarol Stabilization is Delayed in CYP2C9*3 Carriers
TLDR
There is an association between the presence of allelic variants of the gene for cytochrome P450 (CYP 2C9) and anticoagulation problems during the initial 3 to 6 months of acenocoumarol treatment.
Effects of cytochrome P450 2C9 polymorphisms on phenprocoumon anticoagulation status
Our objective was to assess whether there is an association between the presence of allelic variants of the gene for cytochrome P450 (CYP) 2C9 and anticoagulation problems during the initial phase of
Systemic allergic contact dermatitis from intravesical instillation of the antitumor antibiotic mitomycin C
TLDR
6 cases of contact allergy id the antitumor antibiotic mitomycin C from intravesical instillation arc described, and the distribution is suggestive, of systemic contact dermatitis from mitocycin C absorbed from the vesical mucosa.
Comparison of a basic and an advanced pharmacotherapy-related clinical decision support system in a hospital care setting in the Netherlands
TLDR
The advanced CDSS produced a higher proportion of clinically relevant medication alerts, but the number of irrelevant alerts remained high, illustrating and corroborating the need for cyclic testing of technical improvements in information technology in circumstances representative of daily clinical practice.
Tissue Concentrations after a Single-Dose, Orally Administered Ofloxacin in Patients with Diabetic Foot Infections
TLDR
It is shown that orally administered ofloxacin can be an effective treatment for infected diabetic foot lesions and exceeds the minimal inhibitory concentration90 (MIC90) of commonly involved pathogens.
Allergic urticarial rash from oral codeine
TLDR
A case of an urticarial rash from delayed‐type allergy to orally administered codeine is presented and the rôle of patch testing in drug eruptions discussed.
Contact allergy to furazolidone
A case of occupational contact allergy to furazolidone, used as an animal feed additive and as, antimicrobial drug in veterinary medicine, is, described. The patient did nut react to furazolidone 2%
A new VKORC1 allelic variant (p.Trp59Arg) in a patient with partial resistance to acenocoumarol and phenprocoumon
TLDR
It was concluded that treatment failure was most likely a result of partial or total coumarin resistance, and the desired anticoagulation level (target INR 2.5–3.5) was achieved with 18–21 mg phenprocoumon daily with a serum concentration of 28 mg L.
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