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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Filamins as integrators of cell mechanics and signalling
The history, structure and function ofamins are described, which are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes.
An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype
The analysis suggested that most EMT–associated alternative splicing events are regulated by one or more members of the RBFOX, MBNL, CELF, hnRNP, or ESRP classes of splicing factors.
Molecular mechanisms of invadopodium formation: the role of the N-WASP–Arp2/3 complex pathway and coﬁlin
Results indicate that EGF receptor signaling regulatesInvadopodium formation through the N-WASP–Arp2/3 pathway and coﬁlin is necessary for the stabilization and maturation of invadopodia.
A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors
This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophage may contribute to metastasis.
Spatial regulation of β-actin translation by Src-dependent phosphorylation of ZBP1
It is shown that chicken ZBP1 modulates the translation of β-actin mRNA, which is important for cell migration and neurite outgrowth.
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors.
The results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors.
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.
It is shown that macrophages and tumor cells are necessary and sufficient for comigration and invasion into collagen I and that this process involves a paracrine loop.
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
The stages of invadopodium assembly and maturation are dissected and it is shown thatInvadopodia use cortactin phosphorylation as a master switch during these processes to regulate cofilin and Arp2/3 complex–dependent actin polymerization.