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Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
TLDR
It is suggested that INFγ/TNFα and IL-13 have differential effects on CL 2, 3 and 4 in tight junctions, which may lead to increased permeability via different mechanisms. Expand
Defective epithelial barrier function in asthma.
TLDR
The results show that the bronchial epithelial barrier in asthma is compromised, which may facilitate the passage of allergens and other agents into the airway tissue, leading to immune activation and may thus contribute to the end organ expression of asthma. Expand
IFN-gamma is produced by polymorphonuclear neutrophils in human uterine endometrium and by cultured peripheral blood polymorphonuclear neutrophils.
TLDR
It is found that polymorphonuclear neutrophils isolated from normal donors produce IFN-gamma in response to stimulation with LPS, IL-12, and TNF-alpha, indicating that their role in shaping immune responses may be more extensive than previously thought. Expand
Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 alpha+ isoform.
TLDR
Results provide direct evidence from a native epithelium that ZO-1 isoforms perform distinct roles in tight junction assembly and may act as a final rate-limiting step in the synthesis of the tight junction, thereby regulating the time of junction sealing and blastocoele formation in the early embryo. Expand
Unique CD8+ T cell‐rich lymphoid aggregates in human uterine endometrium
TLDR
This new finding of a menstrual cycle‐dependent, phenotypically unique, organized immune cell structure may lead to new insights into the mechanisms by which the endometrium accepts a semiallogeneic graft while providing resistance to infectious organisms. Expand
Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency
TLDR
Evidence is provided that the uterus, and potentially the entire upper reproductive tract, are important sites for the initial events involved in HIV infection, and the hormonal regulation of HIV receptor expression may affect a woman's susceptibility to HIV infection during her menstrual cycle. Expand
Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells.
TLDR
These findings identify a novel proinflammatory action of MMPs in inflammation and suggest that lamina propria myofibroblasts are required to achieve maximal intestinal epithelial immune activation. Expand
Cadherins, catenins and APC in pleural malignant mesothelioma
TLDR
The present study provides the first evidence that β‐catenin accumulates in the nucleus in malignant mesotheliomas, and suggests that a truncated APC gene product may contribute to abnormal Wnt signalling and dysregulation of cell proliferation in mal cancers. Expand
Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo
TLDR
RXFP1 was identified as a potential new therapeutic target for PHT and MF activation status through a selective and significant reduction in portal pressure in pathologically distinct PHT models, through augmentation of intrahepatic NO signaling and a dramatic reduction in contractile filament expression in HSC‐MFs. Expand
TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation.
TLDR
Inhibiting TNF-α or src kinases may be a therapeutic option to normalize barrier integrity and cytokine release in airway diseases associated with barrier dysfunction. Expand
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