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Bupropion: a review of its mechanism of antidepressant activity.
BACKGROUND The mechanism of action of the novel antidepressant bupropion remains unclear after many years of study. A review of the relevant biochemical, in vivo brain microdialysis,Expand
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Buprenorphine treatment of refractory depression.
Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse liabilities, hasExpand
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Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial.
CONTEXT Extracts of Hypericum perforatum (St John's wort) are widely used for the treatment of depression of varying severity. Their efficacy in major depressive disorder, however, has not beenExpand
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A corticosteroid/dopamine hypothesis for psychotic depression and related states.
In recent years, considerable data have emerged that psychotic (delusional) depression is characterized by pronounced increases in hypothalamic-pituitary-adrenal (HPA) axis activity and positiveExpand
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Antidepressant efficacy of sertraline: a double-blind, placebo- and amitriptyline-controlled, multicenter comparison study in outpatients with major depression.
A double-blind, placebo- and amitriptyline-controlled comparison study was performed to evaluate the antidepressant efficacy of sertraline, a specific serotonin uptake inhibitor. Patients withExpand
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Improvement in fluoxetine-associated sexual dysfunction in patients switched to bupropion.
BACKGROUND This study was conducted to determine the effect of bupropion on the sexual functioning of male and female outpatients who developed anorgasmia or delayed orgasm while receiving fluoxetineExpand
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The assessment of tardive dyskinesia.
Available assessment methods for tardive dyskinesia were reviewed under three headings: instrumentation, frequency counts, and rating scales. The more objective methods have better reliability butExpand
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Gender as a Risk Factor for Adverse Events to Medications
An adverse drug reaction (ADR) has been defined by the World Health Organization as any noxious' unintended and undesired effect of a drug which occurs at a dose used in humans for prophylaxis,Expand
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Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication.
OBJECTIVE This review explores the theoretical background for and empirical evidence supporting gender-related differences in pharmacokinetics and pharmacodynamic properties of psychotropicExpand
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Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people
Depression among elderly people with reversible cognitive loss often manifests with concomitant vascular disease and can also precede the development of nonvascular degenerative dementia. Little isExpand
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