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Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.
- V. Fadok, D. Voelker, P. Campbell, J. Cohen, D. Bratton, P. Henson
- Biology, Medicine
- Journal of immunology
- 1 April 1992
The data suggest that macrophages specifically recognize phosphatidylserine that is exposed on the surface of lymphocytes during the development of apoptosis, and suggest that apoptotic lymphocytes lose membrane phospholipid asymmetry and expose phosphorus on the outer leaflet of the plasma membrane. Expand
Hospital-acquired renal insufficiency: a prospective study.
- S. Hou, D. Bushinsky, J. Wish, J. Cohen, J. Harrington
- The American journal of medicine
- 1 February 1983
It is concluded that there is a substantial risk of the development of renal failure in hospital and that the mortality rate due to hospital-acquired renal insufficiency remains high. Expand
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.
By studying the mechanism of DNA fragmentation induced during the interphase death of lymphocytes, this work hopes to understand better the extreme sensitivity of resting lymphocytes to radiation and what may be the common final pathway of programmed cell death. Expand
Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.
It appears that glucocorticoids cause thymocyte death by activating an enzyme that rapidly and extensively degrades DNA, and it is suggested that it may be part of a system for transporting calcium into the nucleus. Expand
Apoptosis and programmed cell death in immunity.
In the immune system there are many examples of programmed cell death, during development of lymphocytes as well as at later stages, after interaction with antigen, which display the morphology of apoptosis. Expand
Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1
It is shown that murine L929 cells infected with prototype reovirus strains type 1 Lang and type 3 Dearing undergo apoptosis and that T3D induces apoptosis to a substantially greater extent than T1L, and it is suggested that interaction of virions with cell surface receptors is an essential step in this mechanism of cell killing. Expand
CARBON DIOXIDE TITRATION CURVE OF NORMAL MAN. EFFECT OF INCREASING DEGREES OF ACUTE HYPERCAPNIA ON ACID-BASE EQUILIBRIUM.
The objective was to establish an experimental procedure and show direct measurements that unequivocally can be assigned as a bona fide immune response to the presence of bicarbonate in the blood of patients with hypercapnia. Expand
Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes
Findings suggest that reovirus-induced inhibition of cellular DNA synthesis and induction of apoptosis are linked and that both phenomena are induced by early steps in the viral replication cycle. Expand
Programmed cell death in the immune system.
- J. Cohen
- Biology, Medicine
- Advances in immunology
This chapter discusses the mechanisms of programmed cell death (PCD), and indicates that there is a death program that all cells follow when they embark on this pathway, even if the specific (or nonspecific) triggers are very different. Expand
Renal conservation of trimethylamine oxide by the spiny dogfish, Squalus acanthias.
Trimethylamine oxide (Oxide) plasma concentrations in the dogfish have been found to be maintained within the narrow range of 60–80 µmol/ml. These levels are maintained in spite of prolonged (up to...