J. Coffin

Publications443
h-index96
Citations29,407
Highly Influential Citations1,234
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HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy
TLDR
Results lead to a simple steady-state model in which infection, cell death, and cell replacement are in balance, and imply that the unique feature of HIV is the extraordinarily large number of replication cycles that occur during infection of a single individual.
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome
TLDR
It is reported here that minus-strand deamination occurred over the length of the virus genome, preferentially at CCCA sequences, with a graded frequency in the 5′→3′ direction.
Flexible use of nuclear import pathways by HIV-1.
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
TLDR
Findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells, and may determine the size of the latent reservoir.
Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses
TLDR
This work presents the most comprehensive and accurate catalog of all full-length and partial HML-2 proviruses, as well as solo LTR elements, within the published human genome to date, and provides evidence for preferential maintenance of proviral elements on gene-rich chromosomes of the human genome and in proximity to gene regions.
New Real-Time Reverse Transcriptase-Initiated PCR Assay with Single-Copy Sensitivity for Human Immunodeficiency Virus Type 1 RNA in Plasma
TLDR
An internally controlled real-time reverse transcriptase-initiated PCR assay that quantifies HIV-1 RNA concentrations down to 1 copy per ml of plasma and had a greater sensitivity than the other assays shown, allowing better characterization of persistent viremia in patients who are receiving antiretroviral therapy and whose HIV- 1 RNA levels are suppressed to below the detection limits of present assays.
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
TLDR
It is reported that the inhibitory immunoregulatory receptor CTLA-4 was selectively upregulated in human immunodeficiency virus–specific CD4+ T cells but not CD8- T cells in all categories of HIV-infected subjects evaluated, with the exception of rare people able to control viremia in the absence of antiretroviral therapy.
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
TLDR
Analysis of longitudinal plasma samples from 40 patients enrolled in the Abbott M97-720 trial suggests that low-level persistent viremia appears to arise from at least two cell compartments, one in which viral production decays over time and a second inWhich viral production remains stable for at least 7 years.
The four classes of endogenous murine leukemia virus: structural relationships and potential for recombination
TLDR
All the murine leukemia virus-related endogenous proviruses of HRS/J mice can be assigned into one of four different classes: the previously characterized ecotropic, xenotropic, and polytropic viruses, as well as a new class the authors have termed modified poly Tropic viruses.
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