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Propranolol dosage, plasma concentration, and beta blockade
The relation of propranolol dose and plasma levels to beta blockade in normal subjects appears to reflect observations in large clinical trials. Expand
Double-blind, placebo-controlled trial of propranolol given once, twice and four times daily in stable angina pectoris: a multicenter study using serial exercise testing.
There was a significant decrease from baseline in the magnitude of ST depression at the final visit, measured at maximal common exercise duration in b.i. i.d. and q.d.'s groups, but not in the placebo group. Expand
Dynamics of beta-adrenoceptor blockade with cetamolol.
Cetamolol is a new beta-adrenoceptor blocking agent shown in animals to have moderate beta 1-adrenoceptor selectivity and partial agonist activity. In healthy normal volunteers, beta 1-adrenoceptorExpand
Dynamics of propranolol dosing schedules
The data indicate that propranolol twice rather than three times a day should be favored when β1‐blockade is needed in therapy and that both twice‐ and three‐times‐a‐day dosing schedules provide well‐sustained 24‐hr β‐ blockade and are probably interchangeable for therapeutic purposes. Expand
Cardioselectivity of Cetamolol Compared With Atenolol and Nadolol
Data from the three studies demonstrate that cetamolol is cardioselective relative to nadolol and that, in contrast to atenolol, cardiosity appears to increase at the higher dose, and that the antagonism of beta‐2‐mediated responses to titrated doses of intravenous isoproterenol by low and high doses of each drug is evaluated. Expand