J. Cliff Jones

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G Protein Activation without a GEF in the Plant Kingdom

Daisuke Urano, J. Cliff Jones, +4 authors Alan M. Jones
PLoS genetics
2012

Animal heterotrimeric G proteins are activated by guanine nucleotide exchange factors (GEF), typically seven transmembrane receptors that trigger GDP release and subsequent GTP binding. In contrast,… (More)

Expanding the functional repertoire of CTD kinase I and RNA polymerase II: novel phosphoCTD-associating proteins in the yeast proteome.

Hemali P. Phatnani, J. Cliff Jones, Arno L. Greenleaf
Biochemistry
2004

CTD kinase I (CTDK-I) of Saccharomyces cerevisiae is required for normal phosphorylation of the C-terminal repeat domain (CTD) on elongating RNA polymerase II. To elucidate cellular roles played by… (More)

Endocytosis of Seven-Transmembrane RGS Protein Activates G- protein Coupled Signaling in Arabidopsis

Daisuke Urano, Nguyen Phan, +5 authors Alan M. Jones
Nature Cell Biology
2012

Signal transduction typically begins by ligand-dependent activation of a concomitant partner that is otherwise in its resting state. However, in cases where signal activation is constitutive by… (More)

Costs of egg ventilation for male common gobies breeding in conditions of low dissolved oxygen

J. Cliff Jones, John D. Reynolds
Animal Behaviour
1999

This study examines the effects of harsh environmental conditions on life history trade-offs in parental care in a marine fish, the common goby, Pomatoschistus microps. We compared male parental care… (More)

C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats.

J. Cliff Jones, Hemali P. Phatnani, Timothy A. J. Haystead, Justin A. MacDonald, S. Munir Alam, Arno L. Greenleaf
The Journal of biological chemistry
2004

The C-terminal repeat domain (CTD) of the largest subunit of RNA polymerase II is composed of tandem heptad repeats with consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. In yeast, this heptad… (More)

The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation.

J. Cliff Jones, Jeffrey W. Duffy, Mischa C Machius, Brenda R. S. Temple, Henrik G. Dohlman, Alan M. Jones
Science signaling
2011

In animals, heterotrimeric guanine nucleotide-binding protein (G protein) signaling is initiated by G protein-coupled receptors (GPCRs), which activate G protein α subunits; however, the plant… (More)

The influence of oxygen stress on female choice for male nest structure in the common goby

J. Cliff Jones, John D. Reynolds
Animal Behaviour
1999

This study examines the role of dissolved oxygen in modifying female mate choice in the common goby, Pomatoschistus microps. Experimental manipulations of nests showed that under normal (saturated)… (More)

Amniotic fluid metabolomic analysis in spontaneous preterm birth.

Ramkumar Menon, J. Cliff Jones, +4 authors Sanmaan K Basraon
Reproductive sciences
2014

OBJECTIVE To identify metabolic changes associated with early spontaneous preterm birth (PTB; <34 weeks) and term births, using high-throughput metabolomics of amniotic fluid (AF) in African American… (More)

Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins.

J. Cliff Jones, Alan M. Jones, Brenda R. S. Temple, Henrik G. Dohlman
Proceedings of the National Academy of Sciences…
2012

Proteins with similar crystal structures can have dissimilar rates of substrate binding and catalysis. Here we used molecular dynamics simulations and biochemical analysis to determine the role of… (More)

Effects of dietary macronutrient composition on the fasted plasma metabolome of healthy adult cats

Ping Deng, J. Cliff Jones, Kelly S. Swanson
Metabolomics
2013

Metabolomics assays have recently been used in humans for the identification of biomarkers for dietary assessment and diseases. The application of metabolomics to feline nutrition, however, has been… (More)

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