J. Clemens

Publications186
h-index50
Citations7,544
Highly Influential Citations98
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Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat
In mammalian brain the expression of peripheral benzodiazepine receptors (PBRs) can be markedly induced following different types of neuronal injury. PBRs are believed to be expressed on non-neuronal… Expand
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Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain
Phospholipase A2 (PLA2) is the key enzyme that initiates the arachidonic acid cascade, which leads to the generation of multiple eicosanoid products. Many of these products are believed to play an… Expand
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Transcription Factor Nuclear Factor-Kappa B is Activated in Neurons after Focal Cerebral Ischemia
Nuclear factor-kappa B (NF-kB) is a multisubunit transcription factor that when activated induces the expression of genes encoding acute-phase proteins, cell adhesion molecules, cell surface… Expand
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Dopamine depletion protects striatal neurons from ischemia-induced cell death.
Infusion of the dopamine neurotoxin 6-hydroxydopamine, unilaterally into the substantia nigra of rats, resulted in a unilateral depletion of dopamine in the ipsilateral striatum. When these rats were… Expand
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Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat
The distribution of beta-amyloid precursor protein (APP) was examined immunocytochemically in rats subjected to focal cerebral ischemia by permanent occlusion of the middle cerebral artery. At 4 and… Expand
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Hypothalamic control of prolactin secretion.
Publisher Summary This chapter emphasizes the current concepts and observations hypothalamic control of prolactin secretion. The regulation of prolactin secretion is exerted by the hypothalamus, and… Expand
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Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats.
BACKGROUND AND PURPOSE After global ischemia, brain levels of hydrogen peroxide, oxygen radicals, and the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) are… Expand
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Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels.
Keoxifene (LY156758) is a new benzothiophene-derived antiestrogen with an extremely low degree of estrogenicity. Administration of 1-20 mg/kg per day inhibited the growth of 7,… Expand
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Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]…
In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzo[b]thiophene… Expand
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Cerebral ischemia: gene activation, neuronal injury, and the protective role of antioxidants.
  • J. Clemens
  • Biology, Medicine
  • Free radical biology & medicine
  • 15 May 2000
A large number of gene products appear after an ischemic insult making it difficult to decipher which genes are involved in tissue injury. Reactive oxygen species (ROS) can influence gene expression… Expand
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