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Induction of plasticity in the human motor cortex by paired associative stimulation.
TLDR
It is proposed that the induced plasticity may represent a signature of associative long-term potentiation of cortical synapses or closely related neuronal mechanisms in the human cortex. Expand
Depression of motor cortex excitability by low‐frequency transcranial magnetic stimulation
TLDR
Spread of excitation, which may be a warning sign for seizures, occurred in one subject and was not accompanied by increased MEP amplitude, suggesting that spread ofexcitation and amplitude changes are different phenomena and also indicating the need for adequate monitoring even with stimulations at low frequencies. Expand
A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex.
TLDR
This study suggests that strict temporal Hebbian rules govern the induction of long-term potentiation/long-term depression-like phenomena in vivo in the human primary motor cortex. Expand
Rapid plasticity of human cortical movement representation induced by practice.
TLDR
Training rapidly, and transiently, established a change in the cortical network representing the thumb, which encoded kinematic details of the practiced movement, suggesting that this phenomenon may be regarded as a short-term memory for movement and be the first step of skill acquisition. Expand
Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation
TLDR
Findings support the view that LTP‐like mechanisms may underlie the cortical plasticity induced by IPAS, as motor evoked potentials induced by unconditioned, single TMS pulses increased after IPAS. Expand
Mechanisms of use-dependent plasticity in the human motor cortex.
TLDR
N-methyl-d-aspartate receptor activation and GABAergic inhibition are identified as mechanisms operating in use-dependent plasticity in intact human motor cortex and similarities in the mechanisms underlying this form of plasticity and long-term potentiation are pointed to. Expand
Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans
TLDR
In vivo evidence of differential modulation of cortical inhibition by blockade of GABA uptake is provided, suggesting that presynaptic GABA autoreceptors may be involved in modulating cortical inhibition in the human motor cortex. Expand
Modulation of associative human motor cortical plasticity by attention.
TLDR
The role of attention in generating motor memories remains controversial principally because it is difficult to separate the effects of attention from changes in kinematics of motor performance from external stimulation in the absence of voluntary movement. Expand
Depression of human corticospinal excitability induced by magnetic theta-burst stimulation: evidence of rapid polarity-reversing metaplasticity.
TLDR
Conditional dependence of cTBS-induced depression of corticospinal excitability on prior neuronal activation suggests that the TBS-model of synaptic plasticity may be closer to synaptic mechanisms than previously thought. Expand
Temporary occlusion of associative motor cortical plasticity by prior dynamic motor training.
TLDR
These findings may link dynamic properties of LTP formation, as established in animal experiments, with human motor memory formation and possibly dynamic motor learning. Expand
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