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Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats.
- A. Zou, Y. H. Ma, +4 authors R. Roman
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
The results suggest that endogenous cytochrome P450 metabolites of arachidonic acid influence renal medullary hemodynamics and the excretion of water and electrolytes. Expand
Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells
- R. Foresti, J. Clark, C. Green, R. Motterlini
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 18 July 1997
The existence of a dynamic equilibrium among free NO, O·̄2, and endogenous glutathione, which might constitute an interactive signaling mechanism modulating stress and adaptive responses in tissues is suggested. Expand
Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction.
- J. Clark, R. Foresti, P. Sarathchandra, H. Kaur, C. Green, R. Motterlini
- American journal of physiology. Heart and…
- 1 February 2000
Exogenously administered bilirubin at concentrations as low as 100 nanomolar significantly restored myocardial function and minimized both infarct size and mitochondrial damage on reperfusion, providing strong evidence for a primary role of HO-1-derived bilirUBin in cardioprotection against reperfusions injury. Expand
Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress.
It is found that hemin-mediated increase in HO-1 protein expression and haem oxygenase activity is associated with augmented bilirubin levels, providing direct evidence that bilirubs generated after up-regulation of the HO- 1 pathway is cytoprotective against oxidative stress. Expand
Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase‐1
- I. Sammut, R. Foresti, +5 authors R. Motterlini
- Chemistry, Medicine
- British journal of pharmacology
- 1 December 1998
It is concluded that up‐regulation of the HO‐1/CO pathway significantly contributes to the suppression of aortic contractility to PE. Expand
Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.
- K. McMillan, D. Bredt, D. Hirsch, S. Snyder, J. Clark, B. Masters
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 December 1992
Rat cerebellar NO synthase, cloned and stably expressed in human kidney 293 cells, contains heme in amounts stoichiometric with the flavins FAD and FMN as evidenced by the appearance of a pyridine hemochrome and a reduced CO difference spectrum with an absorbance maximum at approximately 445 nm. Expand
Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo.
- R. Motterlini, A. Gonzales, R. Foresti, J. Clark, C. Green, R. Winslow
- Circulation research
- 7 September 1998
Evidence is provided for a crucial role of the heme oxygenase/CO pathway in the regulation of blood pressure under stress conditions in vivo and for suppression of the hypertensive response observed at 1 day after surgery. Expand
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.
The results indicate that 20-HETE is an endogenous constrictor of canine renal arcuate arteries and suggests a potential role for this substance in the regulation of renal vascular tone. Expand
Biological aspects of inorganic polyphosphates.
Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum.
Methylenetetrahydrofolate reductase in Clostridium formicoaceticum has been purified to a specific activity of 140 mumol min-1 mg-1 when assayed at 37 degrees C, pH 7.2, in the direction of oxidation… Expand