• Publications
  • Influence
Heme and Iron Metabolism: Role in Cerebral Hemorrhage
Heme and iron metabolism are of considerable interest and importance in normal brain function as well as in neurodegeneration and neuropathologically following traumatic injury and hemorrhagicExpand
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Gene Expression in Blood Changes Rapidly in Neutrophils and Monocytes after Ischemic Stroke in Humans: A Microarray Study
  • Y. Tang, H. Xu, +18 authors F. Sharp
  • Medicine, Biology
  • Journal of cerebral blood flow and metabolism…
  • 4 January 2006
Ischemic brain and peripheral white blood cells release cytokines, chemokines and other molecules that activate the peripheral white blood cells after stroke. To assess gene expression in theseExpand
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Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency.
The second-largest cause of X-linked mental retardation is a deficiency in creatine transporter (CRT; encoded by SLC6A8), which leads to speech and language disorders with severe cognitiveExpand
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The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase.
We have investigated the utilisation of four analogues of creatine by cytosolic Creatine Kinase (CK), using 31P-NMR in the porcine carotid artery, and by mitochondrial CK (Mt-CK), using oxygenExpand
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Genomics of the Periinfarction Cortex after Focal Cerebral Ischemia
Understanding transcriptional changes in brain after ischemia may provide therapeutic targets for treating stroke and promoting recovery. To study these changes on a genomic scale, oligonucleotideExpand
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Creatine Kinase Activity Is Associated With Blood Pressure
Background— We previously hypothesized that high activity of creatine kinase, the central regulatory enzyme of energy metabolism, facilitates the development of high blood pressure. Creatine kinaseExpand
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Creatine Transporter (CrT; Slc6a8) Knockout Mice as a Model of Human CrT Deficiency
Mutations in the creatine (Cr) transporter (CrT; Slc6a8) gene lead to absence of brain Cr and intellectual disabilities, loss of speech, and behavioral abnormalities. To date, no mouse model of CrTExpand
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The Effect of the Creatine Analogue Beta-guanidinopropionic Acid on Energy Metabolism: A Systematic Review
Background Creatine kinase plays a key role in cellular energy transport. The enzyme transfers high-energy phosphoryl groups from mitochondria to subcellular sites of ATP hydrolysis, where it buffersExpand
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Bilirubin Oxidation Products (BOXes) and Their Role in Cerebral Vasospasm after Subarachnoid Hemorrhage
  • J. Clark, F. Sharp
  • Medicine
  • Journal of cerebral blood flow and metabolism…
  • 1 October 2006
Many factors have been postulated to cause delayed subarachnoid hemorrhage (SAH)-induced vasospasm, including hemoglobin, nitric oxide, endothelin, and free radicals. We propose that free radicalsExpand
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High-Performance Vision Training Improves Batting Statistics for University of Cincinnati Baseball Players
Purpose Baseball requires an incredible amount of visual acuity and eye-hand coordination, especially for the batters. The learning objective of this work is to observe that traditional visionExpand
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