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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin.
- G. V. Van Duyne, R. Standaert, P. Karplus, S. Schreiber, J. Clardy
- Chemistry, BiologyJournal of molecular biology
- 5 January 1993
High resolution structures for the complexes formed by the immunosuppressive agents FK506 and rapamycin with the human immunophilin FKBP-12 have been determined by X-ray diffraction and suggest ways in which this catalytic activity could operate.
Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products.
Cloning the Soil Metagenome: a Strategy for Accessing the Genetic and Functional Diversity of Uncultured Microorganisms
Phylogenetic analysis of 16S rRNA gene sequences recovered from one of the libraries indicates that the BAC libraries contain DNA from a wide diversity of microbial phyla, including sequences from diverse taxa such as the low-G+C, gram-positive Acidobacterium,Cytophagales, and Proteobacteria.
Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex.
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The…
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity
- Shenping Liu, R. Cerione, J. Clardy
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 26 February 2002
The structure suggests a structural basis for the negative regulation of transamidation activity by bound nucleotide, and the positive regulation oftransamidation by Ca2+.
Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP
The structure of the FRB domain of FRAP clarifies both rapamycin-independent and -dependent effects observed for mutants ofFRAP and its homologs in the family of proteins related to the ataxia-telangiectasia mutant gene product, and it illustrates how a small cell-permeable molecule can mediate protein dimerization.
d-Amino Acids Trigger Biofilm Disassembly
It is found that d-amino acids found in conditioned medium from mature biofilms of Bacillus subtilis prevent biofilm formation and trigger existing biofilm disassembly, and may be a widespread signal for bio Film disassembly.
Tyrosol is a quorum-sensing molecule in Candida albicans.
- Hao Chen, M. Fujita, Q. Feng, J. Clardy, G. Fink
- BiologyProceedings of the National Academy of Sciences…
- 6 April 2004
The identification of tyrosol as an autoregulatory molecule has important implications on the dynamics of growth and morphogenesis in Candida.
D-Amino Acids Govern Stationary Phase Cell Wall Remodeling in Bacteria
It is found that bacteria produce diverse D-amino acids as well, which accumulate at millimolar concentrations in supernatants of stationary phase cultures and appear to modulate synthesis of peptidoglycan, a strong and elastic polymer that serves as the stress-bearing component of the bacterial cell wall.