• Publications
  • Influence
The potential role of Akt phosphorylation in human cancers.
  • J. Cicenas
  • Biology, Medicine
  • The International journal of biological markers
  • 30 September 2008
Akt/protein kinase B (PKB) is a serine/threonine kinase which is implicated in mediating a variety of biological responses including cell growth, proliferation and survival. Akt is activated byExpand
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Roscovitine in cancer and other diseases.
Roscovitine [CY-202, (R)-Roscovitine, Seliciclib] is a small molecule that inhibits cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site. It is a broad-range purineExpand
  • 81
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The CDK inhibitors in cancer research and therapy
  • J. Cicenas, M. Valius
  • Medicine, Biology
  • Journal of Cancer Research and Clinical Oncology
  • 30 August 2011
Chemical compounds that interfere with an enzymatic function of kinases are useful for gaining insight into the complicated biochemical processes in mammalian cells. Cyclin-dependent kinases (CDK)Expand
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KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma
Cancers are the group of diseases, which arise because of the uncontrolled behavior of some of the genes in our cells. There are possibilities of gene amplifications, overexpressions, deletions andExpand
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Highlights of the Latest Advances in Research on CDK Inhibitors
Uncontrolled proliferation is the hallmark of cancer and other proliferative disorders and abnormal cell cycle regulation is, therefore, common in these diseases. Cyclin-dependent kinases (CDKs) playExpand
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KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer
Pancreatic cancer is a disease that has a very high fatality rate and one of the highest mortality ratios among all major cancers, remaining the fourth leading cause of cancer-related deaths inExpand
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JNK, p38, ERK, and SGK1 Inhibitors in Cancer
Mitogen-activated protein kinases (MAP kinases) are a family of kinases that regulates a range of biological processes implicated in the response to growth factors like latelet-derived growth factorExpand
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Metabolomics in pancreatic cancer biomarkers research
Pancreatic cancer is one of the worst prognoses of all malignancies. More than 40,000 deaths a year from this disease are observed in European Union alone. The only possibly curative treatment ofExpand
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The Aurora kinase inhibitors in cancer research and therapy
  • J. Cicenas
  • Biology, Medicine
  • Journal of Cancer Research and Clinical Oncology
  • 1 March 2016
Abstract Compounds that affect enzymatic function of kinases are valuable for the understanding of the complex biochemical processes in cells. Aurora kinases (AURKs) play a key role in the control ofExpand
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The expression of cancer stem cell markers in human colorectal carcinoma cells in a microenvironment dependent manner.
Numerous lines of evidence support the hierarchical model of cancer development and tumor initiation. According to the theory, cancer stem cells play a crucial role in the formation of the tumor andExpand
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