Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
- S. Dasgupta, K. Rajapakshe, B. O’Malley
- BiologyNature
- 23 March 2018
The Warburg pathway enzyme PFKFB4 acts as a molecular fulcrum that couples sugar metabolism to transcriptional activation by stimulating SRC-3 to promote aggressive metastatic tumours and enhancing tumour growth and metastasis.
Long‐noncoding RNA Atrolnc‐1 promotes muscle wasting in mice with chronic kidney disease
- Lijing Sun, Meijun Si, Zhaoyong Hu
- BiologyJournal of Cachexia, Sarcopenia and Muscle
- 24 July 2018
Long noncoding RNAs (lncRNAs) are defined as >200 nucleotides RNAs but lack the protein‐coding potential, but whether they functionally involve in muscle protein loss has not been investigated.
HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics
HepG2 cells are suggested as a cell-based model in screening for CYP inducers in drug discovery because of more similarity to human liver than the other cell lines in comparisons of the expression of cellular proteins.
A proteomic landscape of diffuse-type gastric cancer
A mutation and proteome dataset for 84 DGC patients is presented, identifying three major classes of DGC and indicating potential targets for therapy and the benefit of proteomic analysis in cancer molecular subtyping.
GPR119: a promising target for nonalcoholic fatty liver disease
- Jin Won Yang, Hyo Seon Kim, K. Kang
- Biology, MedicineThe FASEB Journal
- 1 January 2016
It is demonstrated for the first time that the GPR119 ligand alleviates hepatic steatosis by inhibiting SREBP‐1‐mediated lipogenesis in hepatocytes.
Development of lipidomic platform and phosphatidylcholine retention time index for lipid profiling of rosuvastatin treated human plasma.
- J. Choi, Tae-Eun Kim, Joo-Youn Cho, H. Lee, B. Jung
- Chemistry, BiologyJournal of chromatography. B, Analytical…
- 2014
Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian…
- A. L. Mindikoglu, Mustafa M. Abdulsada, S. Jung
- Biology, MedicineJournal of Proteomics
- 9 January 2020
Geranylgeranylacetone ameliorates acute cochlear damage caused by 3-nitropropionic acid.
- Young Ho Kim, Jae-Jin Song, Sun O Chang
- BiologyNeurotoxicology
- 1 June 2010
Stable and efficient delivery of docetaxel by micelle-encapsulation using a tripodal cyclotriphosphazene amphiphile.
- Yong Joo Jun, V. B. Jadhav, Y. Sohn
- Chemistry, BiologyInternational journal of pharmaceutics
- 17 January 2012
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