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Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain
BACKGROUND Mitochondria have long been proposed to play an important role in the aging process. In the nematode Caenorhabditis elegans, genes important for mitochondrial electron transport chainExpand
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Head direction, place, and movement correlates for cells in the rat retrosplenial cortex.
The retrosplenial cortex is strongly connected with brain regions involved in spatial signaling. To test whether it also codes space, single cells were recorded while rats navigated in an open field.Expand
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Head Direction, Place, and Movement Correlates for Cells in the Rat Retrosplenial Cortex
The retrosplenial cortex is strongly connected with brain regions involved in spatial signaling. To test whether it also codes space, single cells were recorded while rats navigated in an open field.Expand
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Expression of Yeast NDI1 Rescues a Drosophila Complex I Assembly Defect
Defects in mitochondrial electron transport chain (ETC) function have been implicated in a number of neurodegenerative disorders, cancer, and aging. Mitochondrial complex I (NADH dehydrogenase) isExpand
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Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.
Our previous observation that a mitochondrial DNA (mtDNA) homoplasmic C150T transition adjacent to the heavy strand replication origin at position 151 is greatly increased in frequency in ItalianExpand
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The Role of Mitochondria in Drosophila Aging
Understanding how alterations in mitochondrial function in different cells and tissues impacts the aging process remains one of the greatest challenges facing biogerontologists. Here, we discuss theExpand
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Aging: Dial M for Mitochondria
A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported thatExpand
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Two-Element Transcriptional Regulation in the Canonical Wnt Pathway
The canonical Wnt pathway regulates numerous fundamental processes throughout development and adult physiology and is often disrupted in diseases [1-4]. Signal in the pathway is transduced byExpand
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