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  • J. Chládek, J. Martínková, M. Šimková, J. Vaněčková, V. Koudelková, M. Noẑičková
  • Medicine
  • European Journal of Clinical Pharmacology
  • 1998 (First Publication: 6 March 1998)
  • AbstractObjective: The aim of the present study was to investigate the pharmacokinetics and pharmacodynamics of low-dose methotrexate (MTX) in the early phase (3 months) after the start ofExpand
  • M. Hroch, J. Chládek, M. Šimková, J. Vaněčková, J. Grim, J. Martínková
  • Medicine
  • Journal of the European Academy of Dermatology…
  • 2008 (First Publication: 21 November 2007)
  • BACKGROUND Clinical studies of low-dose oral methotrexate (MTX) in the treatment of psoriasis and rheumatoid arthritis document a large interpatient variability in the pharmacokinetics of MTX,Expand
    BACKGROUND Nitrite and nitrate are exhaled in droplets of an aerosol during breathing and can be assayed in the exhaled breath condensate (EBC) as markers of nitrossative stress in the airways ofExpand
  • Miloš Hroch, Jana Tukova, Pavla Doležalová, Jaroslav Chládek
  • Medicine, Chemistry
  • Biopharmaceutics & drug disposition
  • 2009 (First Publication: 1 April 2009)
  • Methotrexate is used widely in the pharmacotherapy of juvenile idiopathic arthritis. Polyglutamates of methotrexate are active metabolites which accumulate in cells including erythrocytes. TheirExpand