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The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
- H. Suzuki, Alistair R R Forrest, +157 authors Y. Hayashizaki
- Medicine, Biology
- Nature Genetics
- 1 May 2009
Using deep sequencing (deepCAGE), the FANTOM4 study measured the genome-wide dynamics of transcription-start-site usage in the human monocytic cell line THP-1 throughout a time course of growth… Expand
Synthetic Double-Stranded RNA Poly(I:C) Combined with Mucosal Vaccine Protects against Influenza Virus Infection
ABSTRACT The mucosal adjuvant effect of synthetic double-stranded RNA polyriboinosinic polyribocytidylic acid [poly(I:C)] against influenza virus was examined under intranasal coadministration with… Expand
Phage conversion of Panton-Valentine leukocidin in Staphylococcus aureus: molecular analysis of a PVL-converting phage, phiSLT.
Staphylococcal Panton-Valentine leukocidin (PVL) is an important virulence factor, which causes leukocytolysis and tissue necrosis. Our previous report on the existence of the PVL genes (lukS-PV and… Expand
SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag
- A. Ryo, N. Tsurutani, +17 authors N. Yamamoto
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 8 January 2008
Human immunodeficiency virus type 1 (HIV-1) utilizes the macromolecular machinery of the infected host cell to produce progeny virus. The discovery of cellular factors that participate in HIV-1… Expand
A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption.
- N. Kohmura, T. Yagi, +6 authors S. Aizawa
- Biology, Medicine
- Molecular and cellular biology
- 1 October 1994
We have isolated a novel nonreceptor tyrosine kinase, Srm, that maps to the distal end of chromosome 2. It has SH2, SH2', and SH3 domains and a tyrosine residue for autophosphorylation in the kinase… Expand
Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections.
Antibody-producing hybridomas of myeloma SP2/O and spleen cells of BALB/c mouse immunized with pertussis toxoid and pertussis toxin were selected by the binding ability of the monoclonal antibody to… Expand
Proline 78 Is Crucial for Human Immunodeficiency Virus Type 1 Nef To Down-Regulate Class I Human Leukocyte Antigen
- T. Yamada, Naotoshi Kaji, T. Odawara, J. Chiba, A. Iwamoto, Y. Kitamura
- Biology, Medicine
- Journal of Virology
- 15 January 2003
ABSTRACT Human immunodeficiency virus type 1 Nef down-regulates human leukocyte antigen class I (HLA-I) in T lymphocytes, and the down-regulation involves the Nef proline-rich domain (PRD) containing… Expand
Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted.
The core protein of hepatitis C virus (HCV) is considered to be cleaved from the N terminus of the large precursor polyprotein by cellular signalase. The HCV cDNA encoding the core protein was… Expand
A sensitive enzyme-linked immunosorbent assay of ochratoxin A based on monoclonal antibodies.
- O. Kawamura, Shigehiro Sato, +4 authors Y. Ueno
- Chemistry, Medicine
- Toxicon : official journal of the International…
We prepared seven monoclonal antibodies (mAbs, OTA.1, 2, 3, 4, 5, 6 and 7) which were reacted with ochratoxin A (OTA), and have developed a specific and highly sensitive enzyme-linked immunosorbent… Expand
Cross-Protection against H5N1 Influenza Virus Infection Is Afforded by Intranasal Inoculation with Seasonal Trivalent Inactivated Influenza Vaccine
- T. Ichinohe, S. Tamura, +14 authors H. Hasegawa
- The Journal of infectious diseases
- 1 November 2007
Abstract Background. Avian H5N1 influenza A virus is an emerging pathogen with the potential to cause substantial human morbidity and mortality. We evaluated the ability of currently licensed… Expand