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Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI.
Glioblastomas (GBMs) are the most common primary brain tumors with poor prognosis. CD133 has been considered a putative marker of cancer stem cells (CSCs) in malignant cancers, including GBMs.Expand
Relation between transfection efficiency and cytotoxicity of poly(2-(dimethylamino)ethyl methacrylate)/plasmid complexes
Abstract Poly(2-(dimethylamino)ethyl methacrylate), p(DMAEMA), with varying molecular weight was synthesized, complexed with pCMV-LacZ plasmid and evaluated as transfection agent in COS-7 and OVCAR-3Expand
Polyurethane-based drug delivery systems.
Polyurethanes (PUs) are formed by a reaction between isocyanates and diols to yield polymers with urethane bonds (-NH-COO-) in their main chain. A great variety of building blocks is commerciallyExpand
Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma.
The high invasiveness and frequent recurrence of lung adenocarcinoma (LAC) are major reasons for treatment failures and poor prognoses. Alterations in microRNAs (miRNAs) expression have been shown inExpand
Effect of Size and Serum Proteins on Transfection Efficiency of Poly ((2-dimethylamino)ethyl Methacrylate)-Plasmid Nanoparticles
AbstractPurpose. The aim of this study was to gain insight into the relation between the physical characteristics of particles formed by a plasmid and a synthetic cationic polymerExpand
2-(Dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents.
Poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) is a water-soluble cationic polymer, which is able to bind to DNA by electrostatic interactions. At a polymer/plasmid ratio above 2 (w/w)Expand
Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes.
In this paper the effect of the topology of plasmid DNA (supercoiled, open-circular and linear) on its binding characteristics with the polymeric transfectant poly((2-dimethylamino)ethylExpand
Stabilization of polymer-based gene delivery systems.
To preserve the size and transfection potential of polymer-plasmid complexes. Freeze-drying and freeze-thawing were used for stabilization of these complexes. The concentration of the sugars is anExpand
Long Term Stability of Poly((2-dimethylamino)ethyl Methacrylate)-Based Gene Delivery Systems
AbstractPurpose. To study the stability of polymer-plasmid complexes (polyplexes) both as an aqueous dispersion and in their lyophilized form. Methods. The characteristics of the polyplexes (size,Expand
Investigation of DNA spectral conformational changes and polymer buffering capacity in relation to transfection efficiency of DNA/polymer complexes.
  • J. Cherng
  • Chemistry, Medicine
  • Journal of pharmacy & pharmaceutical sciences : a…
  • 26 November 2009
PURPOSE The relation between transfection efficiency of DNA/polymer complexes and DNA conformational alterations is investigated. The buffering capacity of several synthetic polymers is also studiedExpand