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Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
Targeted uptake of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner represents a potentially powerful technology. Using prostate cancer as a model, we report docetaxelExpand
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Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.
Nanoparticle (NP) size has been shown to significantly affect the biodistribution of targeted and non-targeted NPs in an organ specific manner. Herein we have developed NPs from carboxy-terminatedExpand
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Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells.
Directed differentiation of embryonic stem (ES) cells is useful for creating models of human disease and could potentially generate a wide array of functional cell types for therapeutic applications.Expand
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Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components.
Micropatterned cellular co-cultures were fabricated using three major extracellular matrix components: hyaluronic acid (HA), fibronectin (FN) and collagen. To fabricate co-cultures with theseExpand
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Bioresorbable silicon electronic sensors for the brain
TLDR
We report materials, device architectures, integration strategies, and in vivo demonstrations of implantable, multifunctional silicon sensors for the brain, for which all of the constituent materials naturally resorb via hydrolysis and/or metabolic action, eliminating the need for extraction. Expand
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The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells.
Paclitaxel-polylactide (Ptxl-PLA) conjugate nanoparticles, termed as nanoconjugates (NCs), were prepared through Ptxl/(BDI)ZnN(TMS)(2) (BDI =Expand
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Effect of residence time on chemical and structural properties of hydrochar obtained by hydrothermal carbonization of water hyacinth
Hydrothermal carbonization of water hyacinth was experimentally conducted in the range of 30 min to 24 h at 240 °C, chemical and structural properties of hydrochar products were investigated.Expand
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Crosslinked dendronized polyols as a general approach to brighter and more stable fluorophores.
Fluorescent, aqueous-soluble, crosslinked dendronized polyols (CDPs) are obtained through a sequential process involving ring-opening metathesis polymerization (ROMP), intra-chain ring-closingExpand
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The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules.
Protein drugs have low bioavailability after oral administration, which is due in part to fast transit of the drugs or drug delivery vehicles through the gastrointestinal tract. Increasing the timeExpand
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Supramolecular polymerization from polypeptide-grafted comb polymers.
  • Jing Wang, Hua Lu, +4 authors Y. Lin
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 28 July 2011
The helical and tubular structures self-assembled from proteins have inspired scientists to design synthetic building blocks that can be "polymerized" into supramolecular polymers through coordinatedExpand
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