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Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma.
We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total of… Expand
Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down‐regulation of TGF‐&bgr;/Smad3 signaling pathway in an Nrf2‐dependent manner
- Chao Bian, Wen-Jun Qin, +6 authors H. Zhe
- Medicine, Chemistry
- Free radical biology & medicine
- 1 December 2018
&NA; Radiation‐induced lung fibrosis (RILF) is a complication of radiotherapy in thoracic cancer patients. Thalidomide (THD) has a therapeutic effect on fibrotic and inflammatory disorders. The… Expand
The combination of Decitabine and EPZ-6438 effectively facilitate adipogenic differentiation of induced pluripotent stem cell-derived mesenchymal stem cells.
- J. Chen, X. Chen, J. Yao, Ming Li, X. Yang
- Biology, Medicine
- Biochemical and biophysical research…
- 13 August 2019
As a novel type of mesenchymal stem cell, induced pluripotent stem cell-derived mesenchymal stem cells (iPMSCs) have huge potential for cell therapy. iPMSCs exhibited the typical characteristics of… Expand
Increased circulating Wnt5a protein in patients with rheumatoid arthritis-associated interstitial pneumonia (RA-ILD).
An early diagnosis of interstitial lung disease (ILD) is important for guiding treatments of rheumatoid arthritis (RA)-associated ILD (RA-ILD) in clinical settings. The non-canonical Wnt signaling… Expand
Effect of TIMP1 transfection on PTEN expression in human kidney proximal tubular cells.
- J. Chen, G. Cai, +6 authors Suo Shi
- Biology, Medicine
- Genetics and molecular research : GMR
- 21 December 2015
To explore the role of metalloproteinase-1 (TIMP-1) tissue inhibitor in the mechanisms of kidney aging, we observed the effects of sense and antisense transfection of TIMP-1 and of metalloproteinase… Expand
Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling
- Yong-Heng Luo, J. Chen, E. Xiao, Qiu-Yun Li, Y. Luo
- Chemistry, Medicine
- Stem cells international
- 10 October 2018
Demethylating agent zebularine is reported to be capable of inducing differentiation of stem cells by activation of methylated genes, though its function in hepatocyte differentiation is unclear. p38… Expand
Clinical significance of Her-2 protein expression in gastric cancer
The clinical significance of plasma CFHR 1-5 in lupus nephropathy.
A deficiency of complement factor H may lead to excessive consumption of C3 and an increase in C3b deposition, which are important pathological characteristics of lupus nephritis. Complement factor… Expand
Su1201 Terlipressin Posttreatment Reduces Intestinal Epithelial Injury Following Intestinal Ischemia Reperfusion via PI3K/AKT Pathway
ILT5 inhibits macrophage-mediated bacterial killing and antigen presentation during sepsis.
Immunosuppression contributes to the mortality of sepsis. However, the underlying mechanism remains unclear. In the present study, we investigated the role of inhibitory receptor immunoglobulin-like… Expand