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Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma.
  • J. Wu, Y. Chen, +5 authors J. Chen
  • Biology, Medicine
  • Genetics and molecular research : GMR
  • 16 May 2014
We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total ofExpand
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Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down‐regulation of TGF‐&bgr;/Smad3 signaling pathway in an Nrf2‐dependent manner
&NA; Radiation‐induced lung fibrosis (RILF) is a complication of radiotherapy in thoracic cancer patients. Thalidomide (THD) has a therapeutic effect on fibrotic and inflammatory disorders. TheExpand
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The combination of Decitabine and EPZ-6438 effectively facilitate adipogenic differentiation of induced pluripotent stem cell-derived mesenchymal stem cells.
As a novel type of mesenchymal stem cell, induced pluripotent stem cell-derived mesenchymal stem cells (iPMSCs) have huge potential for cell therapy. iPMSCs exhibited the typical characteristics ofExpand
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Increased circulating Wnt5a protein in patients with rheumatoid arthritis-associated interstitial pneumonia (RA-ILD).
An early diagnosis of interstitial lung disease (ILD) is important for guiding treatments of rheumatoid arthritis (RA)-associated ILD (RA-ILD) in clinical settings. The non-canonical Wnt signalingExpand
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Effect of TIMP1 transfection on PTEN expression in human kidney proximal tubular cells.
  • J. Chen, G. Cai, +6 authors Suo Shi
  • Biology, Medicine
  • Genetics and molecular research : GMR
  • 21 December 2015
To explore the role of metalloproteinase-1 (TIMP-1) tissue inhibitor in the mechanisms of kidney aging, we observed the effects of sense and antisense transfection of TIMP-1 and of metalloproteinaseExpand
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Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling
Demethylating agent zebularine is reported to be capable of inducing differentiation of stem cells by activation of methylated genes, though its function in hepatocyte differentiation is unclear. p38Expand
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The clinical significance of plasma CFHR 1-5 in lupus nephropathy.
A deficiency of complement factor H may lead to excessive consumption of C3 and an increase in C3b deposition, which are important pathological characteristics of lupus nephritis. Complement factorExpand
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ILT5 inhibits macrophage-mediated bacterial killing and antigen presentation during sepsis.
Immunosuppression contributes to the mortality of sepsis. However, the underlying mechanism remains unclear. In the present study, we investigated the role of inhibitory receptor immunoglobulin-likeExpand