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Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties.
The novel ReO-coordinated cyclic structure of DOTA-Re CCMSH contributes significantly to its enhanced tumor-targeting and renal clearance properties and makes DOTAReCCMSH an excellent candidate for melanoma radiodetection and radiotherapy.
Melanoma-targeting properties of (99m)technetium-labeled cyclic alpha-melanocyte-stimulating hormone peptide analogues.
- J. Chen, Z. Cheng, T. Hoffman, S. Jurisson, T. Quinn
- Biology, ChemistryCancer research
- 15 October 2000
The compact cyclic structure of 99mTc-CCMSH, its resistance to degradation, and its enhanced intracellular retention are the major contributing factors to the superior in vivo tumor targeting properties of 99tc- CCMSH.
In vivo evaluation of 99mTc/188Re-labeled linear alpha-melanocyte stimulating hormone analogs for specific melanoma targeting.
[Molecular cytogenetic study of an extra small chromosome].
The results showed that this chromosome was from the short arm of chromosome of D/G group, and the origin and genetic effects of this chromosome and fertility of the carriers were also discussed.