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Temporal Control of Contractile Ring Assembly by Plo1 Regulation of Myosin II Recruitment by Mid1/Anillin
In eukaryotes, cytokinesis generally involves an actomyosin ring, the contraction of which promotes daughter cell segregation. Assembly of the contractile ring is tightly controlled in space andExpand
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Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Cytokinesis in Schizosaccharomyces pombe requires the function of Cdc15, the founding member of the pombe cdc15 homology (PCH) family of proteins. As an early, abundant contractile ring componentExpand
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The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring
Schizosaccharomyces pombe cdc15 homology (PCH) family members participate in many cellular processes by bridging the plasma membrane and cytoskeleton. Their F-BAR domains bind and curve membranes,Expand
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The Spindle Checkpoint Functions of Mad3 and Mad2 Depend on a Mad3 KEN Box-mediated Interaction with Cdc20-Anaphase-promoting Complex (APC/C)*S⃞♦
Mitotic progression is driven by proteolytic destruction of securin and cyclins. These proteins are labeled for destruction by an ubiquitin-protein isopeptide ligase (E3) known as theExpand
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The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11
Some components of the fission yeast septation initiation network (SIN) localize asymmetrically to spindle pole bodies during anaphase. Symmetric localization of these proteins correlates withExpand
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The Microtubule-destabilizing Activity of Metablastin (p19) Is Controlled by Phosphorylation*
Metablastin (also called p19, stathmin, prosolin, p18, Lap18, and oncoprotein 18) is a highly conserved, cytosolic 149-amino acid polypeptide that is expressed in immature vertebrate cells andExpand
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The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast
The fission yeast F-BAR proteins Cdc15 and Imp2 and their combined SH3-domain partners appear to act as “molecular glue” to stabilize the interaction between the plasma membrane and a complex networkExpand
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The SIN Kinase Sid2 Regulates Cytoplasmic Retention of the S. pombe Cdc14-like Phosphatase Clp1
Cdc14-family phosphatases play a conserved role in promoting mitotic exit and cytokinesis by dephosphorylating substrates of cyclin-dependent kinase (Cdk). Cdc14-family phosphatases have been bestExpand
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Regulation of Phospholipase D2 Activity by Protein Kinase Cα*
  • J. Chen, J. Exton
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • 21 May 2004
It has been well documented that protein kinase C (PKC) plays an important role in regulation of phospholipase D (PLD) activity. Although PKC regulation of PLD1 activity has been studied extensively,Expand
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Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.
The anaphase-promoting complex/cyclosome (APC/C) is a conserved multisubunit E3 ubiquitin (Ub) ligase required to signal the degradation of key cell-cycle regulators. Using single particleExpand
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