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Intracellular antioxidants: from chemical to biochemical mechanisms.
Intracellular antioxidants include low molecular weight scavengers of oxidizing species, and enzymes which degrade superoxide and hydroperoxides. Such antioxidants systems prevent the uncontrolledExpand
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Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation.
Under acidic and mild-temperature conditions, 1-methyl-2-phenylindole was found to react with malondialdehyde (MDA) and 4-hydroxyalkenals to yield a stable chromophore with intense maximal absorbanceExpand
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Mechanism of selenium-glutathione peroxidase and its inhibition by mercaptocarboxylic acids and other mercaptans.
In a systematic search for effectors of glutathione peroxidase, a number of mercaptocarboxylic acids and tertiary mercaptans were found to be strong and specific inhibitors of the enzyme glutathioneExpand
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Glutathione oxidase activity of selenocystamine: a mechanistic study.
Selenocystamine (RSe-SeR) was shown to catalyze the oxygen-mediated oxidation of excess GSH to glutathione disulfide, at neutral pH and ambient PO2. This glutathione oxidase activity required theExpand
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Reactions of N-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Mechanistic aspects of the colorimetric assay of lipid peroxidation.
Under specific acidic conditions, both malondialdehyde (1, MDA) and 4-hydroxynonenal (2, 4-HNE) react with N-methyl-2-phenylindole (3) to give the same chromophoric cyanine 4 with maximal absorbanceExpand
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Structure and epimerase activity of anthocyanidin reductase from Vitis vinifera.
Together with leucoanthocyanidin reductase, anthocyanidin reductase (ANR) is one of the two enzymes of the flavonoid-biosynthesis pathway that produces the flavan-3-ol monomers required for theExpand
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Essentiality of omega 3 fatty acids for brain structure and function.
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Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol.
A new spectrophotometric assay of superoxide dismutase (SOD) activity is described. The assay is based on the SOD-mediated increase in the rate of autoxidation ofExpand
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Enzymatic Protection Against Peroxidative Damage in Isolated Brain Capillaries
Abstract: The content of polyunsaturated fatty acids, the activities of superoxide dismutase (SOD), glutathione per‐oxidase, glutathione reductase, and catalase, and the concentration of reducedExpand
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Chapter 2 – Some chemical and biochemical constraints of oxidative stress in living cells*
The chapter emphasizes on the thermodynamic, kinetic, and biochemical constraints that explain why the production of free radicals and peroxides and the cost of their elimination are inseparable fromExpand
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