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ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.
Conscious, preconscious, and subliminal processing: a testable taxonomy
Experimental and Theoretical Approaches to Conscious Processing
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
Structural comparison with ELIC, a bacterial homologue from Erwinia chrysanthemi solved in a presumed closed conformation, shows a wider pore where the narrow hydrophobic constriction found in ELIC is removed, consistent with a model of pore opening based on both quaternary twist and tertiary deformation.
Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei
- R. Klink, A. D. K. d’Exaerde, M. Zoli, J. Changeux
- Biology, ChemistryThe Journal of Neuroscience
- 1 March 2001
Neurons in the DA nuclei thus exhibit a diversity of nAChRs that might differentially modulate reinforcement and motor behavior.
Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
The results strongly support the idea that the β2-containing neuronal nicotinic acetylcholine receptor is involved in mediating the reinforcing properties of nicotine.
Nicotinic receptors at the amino acid level.
Electron microscopy, affinity labeling, and mutagenesis experiments, together with secondary structure predictions and measurements, suggest an all-beta folding of the N-terminal extracellular domain, with the connecting loops contributing to the ACh binding pocket and to the subunit interfaces that mediate the allosteric transitions between conformational states.
Development of Elementary Numerical Abilities: A Neuronal Model
The computer simulations account for several phenomena in the numerical domain, including the distance effect and Fechner's law for numbers, and demonstrate that infants' numerosity detection abilities may be explained without assuming that infants can count.
Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice
It is established that α6β2* nAChRs are functional and sensitive to α-conotoxin MII inhibition, and somato-dendritic (nonα6)α4β2- nA ChRs most likely contribute to nicotine reinforcement.
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
- A. Taly, P. Corringer, D. Guédin, P. Lestage, J. Changeux
- Biology, PsychologyNature Reviews Drug Discovery
- 1 September 2009
Recent advances in the understanding of the assembly, activity and conformational transitions of nicotinic receptors are described, as well as developments in the therapeutic application of Nicotinic receptor ligands, with the aim of aiding novel drug discovery by bridging the gap between these two rapidly developing fields.